摘要
目的探讨奥氮平辅助治疗难治性抑郁症的疗效及安全性。方法34例难治性抑郁症患者在原抗抑郁剂盐酸帕罗西汀治疗的基础上合用奥氮平。观察时间8周,于治疗前及治疗后1、2、4、8周末采用汉米尔顿抑郁量表、临床总体印象量表—严重程度量表评定疗效,采用副反应量表评定药物不良反应。结果自治疗2周末始,汉米尔顿抑郁量表、临床总体印象量表—严重程度量表评分比治疗前均有减少,差异有显著性。治疗8周末痊愈率12.90%,有效率51.61%,无效率35.49%,不良反应较轻。结论奥氮平辅助治疗难治性抑郁症有效安全。
Objective To explore the efficacy and safety of olanzapine as an augment in the treatment of patients with refractory depression. Methods A total of 34 patients with refractory depression were treated with former antidepressant paroxetine combined with olanzapine for 8 weeks. The patients were assessed with HAMD, CGI-SI and TESS before the treatment and at the end of the first second, foruth and eighth week of the treatment. Results Compared with pretreatment, the scores of HAMD and CGI-SI were significantly reduced from the end of the second week after treatment. Aeeordlng the score-reduction rate of HAMD, 12.90% were assessed recovered and 51.61% were effective at the end of 8th week. Meanwhile, the other 35.49% were ineffective.. Side effects were mild and tolerable. Conclusion Small dose of olanzapine can be effectively and safely used as an augment in the treatment of patients with refractory depression.
出处
《中国健康心理学杂志》
2008年第9期1049-1051,共3页
China Journal of Health Psychology
