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氯胺酮不同给药方法对脓毒症大鼠血清TNF-α变化的影响 被引量：2

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摘要 目的:探讨氯胺酮不同给药方法对脓毒症大鼠血清肿瘤坏死因子-α(TNF-α)的影响。方法:选择健康雄性SD大鼠24只,随机分为四组:对照组、CLP(盲肠结扎加穿孔)组、氯胺酮(KT)组和KT组。对照组开腹后不做任何处理,其余各组均行CLP,CLP后开始计时。KT组于术前30 min,KT组于CLP后2 h开始,均经尾静脉给予氯胺酮5 mg.kg-1.h-1至CLP5 h,术毕用酶联免疫吸附试验检测血清TNF-α。结果:对照组、KT、KT组血清TNF-α均低于CLP组(P<0.05),KT与KT组比较差异有显著性(P<0.05)。结论:氯胺酮不同给药方法对脓毒症大鼠均有保护效应,术前输注效果更佳。
作者 王晓鹏
机构地区 山西医科大学第二医院
出处 《临床医药实践》 2008年第6期415-416,共2页 Proceeding of Clinical Medicine
关键词 脓毒症 氯胺酮 肿瘤坏死因子-Α
分类号 R971.1 [医药卫生—药品]
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共引文献12

同被引文献22

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临床医药实践
2008年 第6期

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