摘要
目的：了解观察伤后输注纤维结合蛋白（Ｆｎ）对大鼠血管内皮细胞（ＶＥＣ）损伤修复的作用．方法：用大鼠尾静脉损伤及左股骨粉碎性骨折模型，实验分Ｆｎ治疗组和等渗盐水对照组，Ｆｎ治疗组于伤后２小时，输注Ｆｎ１．７ｍｇ／１００ｇ体重．结果：输注Ｆｎ可使血浆Ｆｎ和腹腔巨噬细胞（Ｐ－Ｍψ）表面Ｆｎ水平增高、Ｐ－Ｍψ吞噬功能增强、循环内皮细胞（ＣＥＣ）数量减少、内皮损伤区网格状支架增多、槽状结构变浅且有ＥＣ爬行现象．结论：伤后输注Ｆｎ促进损伤内皮的修复有一定作用．
Aim: To study the repair effect of fibronectin (Fn) on vascular endothelial cells (VEC) in post injured rats infused with Fn. Methods: Rats were inflicted with model injury of tail vein and femar fracture, then divided into a Fn treated group and a normal sodium treated (NS treated) group. Fn (1.7mg/100g weight) was infused in the Fn treated group 2 hours after injury. Results: Fn might increase the plasma Fn and surface Fn of peritoneal macrophage cells, improve the function of peritoneal macrophage cells and decrease the number of circulating endothelial cells (EC), and there were more crawlling endothelial cells (EC) after Fn treatment. Conclusion: Fn can improve the repair of injured EC.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1997年第5期305-307,共3页
Chinese Journal of Trauma
