摘要
目的:研究非甾体类抗炎药物对妇科腹腔镜术后超前镇痛的效果。方法:66例择期行妇科腹腔镜手术的患者,随机分为三组,各22例。麻醉诱导前A组(静注氟比洛芬酯50 mg),B组(氯诺昔康8 mg);C组静注等量生理盐水。每组患者于完全清醒时,清醒后0.5 h、1 h、2 h、8 h、24 h进行VAS评分及不良反应观察。结果:A组完全清醒后8 h内和B组完全清醒后2 h内各时点的VAS评分,均明显低于C组相应时点(P<0.05),且完全清醒后8 h内各观察点VAS,氟比洛芬酯组明显低于氯诺昔康组;与C组比较,A、B两组未见明显不良反应。结论:麻醉诱导前预注氟比洛芬酯或氯诺昔康,均能减轻妇科腹腔镜手术后疼痛,以氟比洛芬酯效果较好。
Objective： To study effects of preemptive analgesia with non-steroidal anti-inflammatory drugs （NSAIDs）. Methods： 66 adult patients（ ASA Ⅰ -Ⅱ ） scheduled to take gynecological laparoscopic surgery were randomly divided into three groups（each group 22）. Before induction of anesthesia, flurbiprofen axetil microsphere injection 50 mg was given IV in Group A, lornoxicam 8 mg was adiministered IV in Group B, and in Group C, equivalent dose of O. 9% NaCl was injected as control. The pain score with visual analogue scale （VAS） , incidence of adverse events were recorded at the emergence from anesthesia, O. 5, 1, 2, 8 and 24 h after emergence. Results ： at each observed point during 8 h after emergence, the VAS of patients in group A were significantly lower than in group B or group C （ P 〈 O. 05 ）. The VAS of patients in group B were markedly less than in group C during 2 h after emergence （ P 〈 O. 05 ）. Furthermore, no significant difference was found for side effects in three groups. Conclusion ： Before induction of anesthesia, the administration of flurbiprofen axetil microsphere injection or lornoxicam IV in patients undergoing gynecological laparoscopic surgery provide adequate preemptive analgesic effect, and flurbiprofen axetil microsphere may be a better choice.
出处
《军医进修学院学报》
CAS
北大核心
2008年第4期308-309,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
消炎药
非甾类
氟比洛芬酯
氯诺昔康
超前镇痛
妇科外科手术
腹腔镜检查
anti-inflammatory, non-steroidal
preemptive analgesia
flurbiprofen axetil
lornoxicam
gynecological sursical Procedures
laparoscopy
