摘要
目的观察氯胺酮(ketamine,KT)对丙泊酚(propofol,P)催眠作用的影响,为建立氯胺酮与丙泊酚复合麻醉提供实验依据。方法将小鼠分为3组:丙泊酚组(P组)、氯胺酮组(KT组)、丙泊酚+氯胺酮组(P+KT组),每组10只。分别用静脉注射、腹腔注射和口服等3种给药途径来观察药物对小鼠翻正反射持续时间(持续期)的影响。结果静脉注射,P25+KT10组的持续期长于P25组和KT10组(P<0.01);腹腔注射,P75+KT30组的持续期长于P75组和KT30组(P<0.01);口服,P200+KT100组的持续期长于P200组和KT100组(P<0.01)。结论无论口服、腹腔注射或静脉注射,氯胺酮均可增强丙泊酚对小鼠的催眠作用。
Objective To investigate the effect of ketamine （KT） on the hypnosis of propofol （P） as an experimental work to support the clinical use of compound anesthesia of KT and P. Methods Mice in 3 groups （P group, KT group and P ＋ KT group, n = 10 each） were given the two drugs singly or in combination via one of the three routes iv, ip and po. The time lasted for the loss of righting reflex, i.e. the persistent period, was taken to measure the hypnotic effect in each case. Results After intravenous injection： the persistent period was longer in the P25 ＋ KT10 group than in the P25 and KT10 groups [ （9.2 ±2.4） min vs. （4.4 ± 1.5） and （2.0 ± 1.0） min, P 〈0.01 ]. After intraperitoneal injection： the persistent period was longer in the P75 ＋ KT30 group than in the P75 and KT30 groups [ （50.6 ± 13.9） min vs. （ 14.8 ± 6.7） min and （ 1.6 ± 1.3 ） min, P 〈 0.01 ] ; After oral intake ： the persistent period was longer in the P200 ＋ KT100 group than in the P200 and KT100 groups [ （51.2 ± 30.9 ） min vs. （ 1.3 ± 0.9 ） min and （5.6 ± 6.3 ） min, P 〈0. 01 ]. Conclusion No matter which route are the drugs administered, ketamine can enhance the hypnosis of propofol.
出处
《徐州医学院学报》
CAS
2008年第8期550-552,共3页
Acta Academiae Medicinae Xuzhou
基金
国家自然科学基金(30471657
39970715)
江苏省自然科学基金(BK2001143)
