摘要
目的观察子宫动脉栓塞术(UAE)和米非司酮(mifepristone)治疗子宫肌瘤的临床疗效、副作用及复发率。方法子宫肌瘤患者共80例,随机分为2组,UAE组34例,行超选择性子宫动脉栓塞术。米非司酮组46例,口服米非司酮3个月。观察2组治疗前后子宫肌瘤大小、子宫体积变化、不良反应及复发率。结果2种治疗方法均能明显改善临床症状,缩小子宫体积和肌瘤体积(P<0.01),且短期内米非司酮组比UAE组缩小明显(P<0.05)。UAE后子宫肌瘤无复发,米非司酮治疗后有复发。UAE前后血清性激素变化差异无统计学意义(P>0.05),而米非司酮治疗前后变化差异有统计学意义(P<0.05),但可恢复。结论UAE和米非司酮均为保守性治疗子宫肌瘤的有效方法,使临床症状减轻或消失。但米非司酮停药后有复发,适用于术前辅助用药和围绝经期治疗。
Objective To observe the clinical efficacy, side effects and recun＇ent rate of uterine artery embolizafion （UAE） and mifepristone on the treatment of uterine fibroids. Methods 80 patients with uterine fibroids were divided into two groups randomly. In group UAE, 34 cases were performed UAE ,and in group mifepristone, 46 cases were treated with mifepristone for three months. The symptoms, size of uterine fibroids, side effects, recun-ent rate and other related data were analyzed in patients with two different treatments. Results The symptoms were improved obviously, and the size of the uterine as well as leiomyoma was significantly reduced in both groups （ P 〈 0.01 ）. Compared with the group UAE, the size of the uterine and leiomyoma reduced more significant in group mifepristone （ P 〈 0.05）. However, the leiomyoma was easy to recur after stopping the treatment of mifepriston, while there was no recurrence happened in group UAE. Moreover, ovarian hormone secretion was affected by mifepristone treatment but not UAE. Conclusion Both UAE and mifepristone regimen are effective conservative methods to treat uterine fibroids. Since the leiomyoma is easy to recur due to discontinued medication, mifepristone is usually used in preoperative medication or perimenopausal patients.
出处
《河北医药》
CAS
2008年第9期1289-1291,共3页
Hebei Medical Journal
关键词
子宫肌瘤
米非司酮
子宫动脉栓塞术
uterine fibroids
mifepristone
uterine artery embolization
