摘要
目的观察氟桂利嗪对脑缺血复灌后学习记忆行为的影响。方法采用大、小鼠夹闭双侧颈总动脉,脑缺血后复灌模型,动物分组给药,人工常规饲养7d后,检测小鼠跳台错误次数、大小鼠Y型迷宫试验来观察大、小鼠学习记忆行为的改变。结果氟桂利嗪可以减少小鼠跳台试验次数,延长小鼠跳台试验的潜伏期,减少大、小鼠Y型迷宫试验中的错误反应次数。结论脑缺血复灌损伤可以导致记忆障碍,氟桂利嗪对脑缺血后记忆障碍具有一定的改善作用。
[Objective] To investigate the effects of Flunarizine on learning and memory in mice or rats after cerebral ischemia-reperfusion damages. [Methods] The models of clamping the bilateral common carotid arteries （CCA） and ischemia followed by reperfusion were used, Kun-Ming mice and Wistar rats were randomly divided into 3 groups and administered. After the usual rear for 1 week, step down, Y-Labyrinth tests were used to measure the changes of the ability to learn and memory in mice and rats, respectively. [Results] The error number of mice in step-down test and shock number of learning or memory,escaple time in Y-labyrinth of rats were decreased. Stepdown latencies were increased. [Conclusion] Results showed that cerebral ischemia-reperfusion damage could result in dysmnesia, Flunarizine could improve the memory retention after ischemia.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第15期2146-2148,共3页
China Journal of Modern Medicine
关键词
氟桂利嗪
脑缺血再灌注损伤
学习记忆
Flunarizine
cerebral ischemia-reperfusion injury
learning and memory
