摘要
目的研究急性ST段抬高心肌梗死（STEMI）发病后不同时间溶栓治疗对血管再通的影响。方法48例STEMI静脉溶栓治疗患者，根据发病后不同时间溶栓分为四组，A组≤3h，B组3～6h，C组6—12h。结果三组血管再通率分别为83．3％、75．0％、37．5％，前两组与后一组间比较，差异有显著性（P〈0．05），出血并发症差异无显著性，病死率分别为0％、3．8％、12．5％。结论血管再通率与发病至溶栓的时间呈负相关，STEMI发病3h内溶栓治疗，血管再通效果最好，住院期间死亡率最低，3—6h次之，而对于发病时间6—12h的患者溶栓治疗效果不显著，但仍有一定疗效。
Objective To study the effect of thrombolytic therapy on blood vessel reperfusion in different times after ST - segment elevation myocardial infarction（STEMI）. Methods Forty eight patients with STEMI were divided into three groups according to different times after intravenous thrombolytic therapy. The groups were A（≤ 3h）, B （3 -6h） and C （6 - 12h）. Results Reperfusion rate of the three groups were 83.3% ,75.0% and 37.5% respectively, with significant difference between the former two groups and the later one groups （P 〈 0. 05 ）. The hemorrhage complication without significant difference of the three groups. The mortality rate were 0,3.8% and 12.5% respectively. Conclusion The reperfusion rate was opposite related with the duration from onset of STEMI to thrombolytic. In the patients, within 3h after onset STEMI, the reperfusion effect of blood vessels was the best, within 3 - 6h was better, while within 6-12h had not significant effect, but still had some effect.
关键词
急性ST段抬高型心肌梗死
溶栓治疗
血管再通率
ST - segment elevation myocardial infarction Thrombolytie therapy The reperfusion rate of blood vessels
