摘要
为探讨脑缺血后出现性功能紊乱的机理.应用沙土鼠急性脑缺血动物模型,在5分钟和10分钟脑缺血后再灌注4小时～14天,对腺垂体内促性腺激素细胞的动态变化进行了免疫细胞化学和电镜观察.结果表明:脑缺血后4小时,促性腺激素免疫阳性细胞密度和染色强度及其超微结构均发生明显改变.缺血5分钟再灌注后发生的变化是可逆的,可在1～2周内恢复.10分钟脑缺血再灌注后改变加重,出现明显的组织病理学损伤,而致细胞合成和分泌功能受到抑制,至缺血后2周仍未完全恢复.结论:细胞损伤程度与脑缺血时间长短密切相关.腺垂体内促性腺激素细胞的损害是引起性功能紊乱的重要形态学依据.
Mongolian gerbils were used as animal models for transient cerebral ischemia to explore the potential mechanism of disorder in sexual function after acute cerebral ischemia. The animals were made to recirculate at 4 hours to 14 days following transient cerebral ischemia. The morphological changes of gonadotropic cells in the pituitary gland were observed by immunocy-tochemistry and electron microscopy. The results showed that remarkable changes in the density, staining activity and ultrastructure of gonadotropic cells accurred 4 hours after cerebral ischemia. Changes of gonadotropic cells were found to be reversible within 1~2 weeks during recirculation after five minutes of cerebral ischemia. Gonadotropic cells were seriously damaged and their function of synthesis and secretion was inhibited during recirculation after ten minutes of cerebral ischemia. The degree of damage was closely related to the time of ischemia. The damage of gonadotropic cells in the pituitary gland was important morphologic basis of changes in sexual function after ischemia.
出处
《解剖学杂志》
CAS
CSCD
北大核心
1997年第5期462-468,共7页
Chinese Journal of Anatomy
