摘要
目的评价ＩＬ－２／ＬＡＫ细胞局部过继免疫疗法在头颈部恶性肿瘤治疗中的疗效。方法对３３例头颈部恶性肿瘤患者进行局部过继免疫治疗，采用ＩＬ－２每日１０～２０万单位局部注射，共１０天；于ＩＬ－２治疗的第４～８天同时于局部注射ＬＡＫ细胞１．０×１０８～５．０×１０８／ｄ。结果完全缓解１例，部分缓解６例，好转２０例，稳定６例，治疗总缓解率２１．２％，总有效率８１．８％。治疗后１，２，３年生存率分别为９６．３％、８３．３％、和７５．０％。组织病理学检查证实免疫治疗后肿瘤局部大量ＣＤ３、ＣＤ４阳性Ｔ淋巴细胞浸润。治疗过程中未见严重的毒副作用。结论局部应用ＬＡＫ细胞与ＩＬ－２治疗头颈部恶性肿瘤疗效明显，方法安全。
s Objective To evaluate treatment effects of local adoptive immunotherapy in 33 cases with head and neck cancer. Methods IL 2 1×10 5～2×10 5U per day was injected into tumor for 10 days; during the 4th～8th day LAK cells 1.0×10 8～5.0×10 8 per day were combined with IL 2 injection. Then we analysized clinical effect, immunopathology, side effects, etc. Results CR was seen in 1 case; PR in 6, MR in 20 cases, and SD in 6 cases. The one , two and three year survival rate was 96.3%, 83.3% or 75.0% respectively. The results of histopathology showed that there were large amount of T lymphocytes (CD3+/4+) infiltrating in the tumor area after immunotherapy. No serious side effects were found during the course of the treatment. Conclusion Local injection of IL 2/LAK can be used as immunotherapy for head and neck cancer.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
1997年第6期454-456,共3页
Chinese Journal of Oncology
