摘要
目的：比较尼群地平及卡托普利治疗对自发性高血压大鼠（ＳＨＲ）左心室肥厚及左心室小动脉重构的疗效。方法：选用ＳＨＲ及Ｗｉｓｔａｒ－Ｋｙｏｔｏ大鼠（ＷＫＹ）７２只，随机分成１４周龄的ＳＨＲ１４组和ＷＫＹ１４组，２８周龄的ＳＨＲ尼群地平组（３０ｍｇｋｇ－１／ｄ）和卡托普利组（５０ｍｇｋｇ－１／ｄ），２８周龄的高血压对照组（ＳＨＲ２８组）和正常对照组（ＷＫＹ２８组）。每组１２只。观察指标包括左心室心肌重量与体重比值（ＬＶＭ／ＢＷ），冠状动脉血流量，心肌毛细血管密度（ＰＤ），两种不同管径小动脉管壁面积与腔径比值（Ａ／Ｒ），心肌胶原含量及心肌钙离子浓度。结果：１４周龄的ＳＨＲ已有左心室重构，除左心室肥厚外，心肌毛细血管密度减少（２６４±４２ｖｓ．３７２±７１μｍ／μｍ３，Ｐ＜０．０５），Ａ／Ｒ增加，心肌胶原含量（４．６２±０．８４ｖｓ．３．２７±０．９４ｍｇ／１００ｍｇ干重，Ｐ＜０．０５）及心肌钙离子浓度增加，尼群地平或卡托普利降压治疗１４周后，两组的左心室重构的异常表现均有消退或减轻。结论：尼群地平与卡托普利均能逆转ＳＨＲ左心室及心肌血管重构，在降压程度相同时其逆转效果相似。
bjective:To compare the effect of the nitrendipine with captopril on regressing coronary vascular remodeling in spontaneously hypertensive rats (SHRs) with left ventricular hypertrophy.Methods:SHRs 14 weeks and agematched WisterKyoto rats (WKY) were randomly divided into six groups (n=12 in each).Two groups of control(one in each strain) were sacrificed,WKY14 and SHR14;the other four groups included ①SHRs treated with nitrendipine(30 mg·kg-1/d) for 14 weeks(SHRni28);②SHRs treated with captopril (50 mg·kg-1/d)for 14 weeks(SHRcp28);③SHRs without treatment for 14 weeks(SHR28);④WKY rats of 28week old (WKY28).The main parameters investigated were as follows:The ratio of left ventricular mass to body weight (LVM/BW);myocardial capillary density (PD);the ratio of wall area to lumen diameter (A/R) of two different lumen arteries;coronary flow;myocardial collagen concentration and myocardial[Ca2+].Results:SHR14 group showed left ventricular remodeling,which included LVH,increase of myocardial collagen concentration(462±084 vs.3.27±0.94 mg/100 mg dry wt,p<0.05),A/R and myocardial [Ca2+];decrease of PD(264±42 vs.372±71 μm/μm3,p<0.05) and coronary reserve.After 14week treatment with nitrendipine or captopril,the abnormal LV remodeling regressed.All the mentioned parameters were near the normal level as in WKY28.Conclusion:As the antihypertensive effect of both drugs is similar,the coronary remodeling effect of two drugs resembles.
出处
《中国循环杂志》
CSCD
北大核心
1997年第6期462-464,共3页
Chinese Circulation Journal
关键词
高血压
左心室肥厚
心肌血管重构
尼群地平
Spontaneously hypertensive rats
Coronary vascular remodeling/regression
Nitrendipine
Captopril
