摘要
对原发性高血压（EH）组件肥胖病人27例（BMI≥25kg／m2）、非肥胖病人30例（BMI＜25kg／m2）、正常对照组20例全部进行口服葡萄糖耐量试验，其中66例同时行胰岛素释放试验。测定分析各个时相的血糖、血胰岛素水平，计算胰岛素敏感指数。结果显示，在EH存在糖代谢紊乱的早期，已存在显著的高胰岛素血症和胰岛素抵抗，这些改变在伴有肥胖的EH病人中更为严重。故监测血胰岛素水平，不仅为判定胰岛素抵抗程度所必需，而且可以作为对EH病人代谢紊乱进行临床评估和干预的指标。
We studied 27 obese essential hypertensive, 30 nonobese hypertensive and 20 control subjects. Serum glucose were examined during glucose tolerance test in all the subjects,serum insulin levels were determined and insulin sensitivity index were caculated in 66 of them simultaneously. The results showed that significant hyperinsulinemia and insulin resistance were already present in the early stage of glucose metabolic dysfunction due to essential hypertension.The changes were more severe in obese hypertensives. It is necessary to monitor serum insulinlevels not only for the determination of the degree of insulin insistance but also for the evaluationand intervention of metabolic dysfunction due to essential hypertension.
出处
《北京医学》
CAS
北大核心
1997年第6期330-333,共4页
Beijing Medical Journal
