摘要
目的：为探讨内皮素（ＥＴ）和降钙素基因相关肽（ＣＧＲＰ）在脑梗塞中的作用及相互关系。方法：应用放射免疫分析法同步测定４０例脑梗塞患者和３０例正常对照者血浆ＥＴ和ＣＧＲＰ含量。结果：脑梗塞急性期血浆ＥＴ和ＣＧＲＰ含量均较正常对照组显著升高（Ｐ＜０．０１），ＣＧＲＰ／ＥＴ值显著低于正常对照组（Ｐ＜０．０１），中－重度脑梗塞组血浆ＣＧＲＰ／ＥＴ值显著低于轻度组。结论：ＥＴ为致损伤因素，急性期ＣＧＲＰ的升高可能是一种代偿机制，且与其拮抗ＥＴ的作用有关；ＣＧＲＰ与ＥＴ间平衡紊乱可能是脑梗塞发生发展的重要因素，血浆ＣＧＲＰ／ＥＴ值可做为判断病情程度及预后的一项参考指标。
Objective:To investigate the relation and effects of endothelin(ET) and calcitonin gene related peptide (CGRP) on cerebral infarction. Methods:Plasma levels of ET and CGRP were concomitantly measured by radioimmunoassay in 40 patients with ceredral infarction and in 30 normal controls. Results: Plasma levels of ET and CGRP were increased significantly in the acute stage of cerebral infarction in comparison with those in the normal controls (P<0.01). The ratio of plasma CGRP level to plasma ET level in acute stage was significantly lower than that in the control group (P<001). The ratio of CGRP/ET in the moderate and serious cases was lower than that in slight cases (P<0.01). Conclusions:ET played a deleterious role in cerebral infarction. The increase of CGRP might be a compensatory mechanism related to the antagnistic effect on ET. The ratio of CGRP/ET could reflect the degree of interaction between ET and CGRP. The ratio of plasma CGRP to plasma ET level might be used as a reference index to recognize the severity and prognosis of cerebral infarction.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1997年第6期596-598,共3页
Journal of China Medical University
基金
辽宁省自然科学基金
