摘要
多发性硬化(MS)是一种与自身免疫相关的中枢神经系统病变,因对其发病机制缺少了解,过去主要应用免疫抑制进行治疗。笔者对广谱免疫抑制治疗MS的利弊进行分析,并将近几年有关细胞因子、趋化因子和黏附因子对MS作用的研究进展及为此提供的免疫治疗新方向进行综述。
Multiple sclerosis（MS）is a kind of autoimmune-associated central nervous system disease.Because of the limited information about the mechanism,MS has been treated by immunosuppressive agents.In this review,the authors will compare the benefits with facing risks of conventional immunosuppressive treatments.Current and future immunosuppressive and immunomodulating therapeutic approaches at the level of cytokine,chemokine and adhesion factors are also discussed in this review.
出处
《中国康复理论与实践》
CSCD
2008年第8期736-738,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金项目(No.90709011
30472184)
国家重点基础研究计划-973计划项目(No.2003CB517104)
关键词
多发性硬化
免疫调节
趋化因子
综述
multiple sclerosis
immunomodulation
chemokine
review
