摘要
目的观察肾衰养真胶囊对慢性肾衰竭(CRF)营养不良大鼠的肾保护作用。方法予0.5%腺嘌呤和4%酪蛋白混合饲料喂养制作CRF营养不良大鼠模型,观察其营养不良发生时间,符合条件的随机分为正常组、模型组、肾衰养真胶囊组和开同组。经肾衰养真胶囊灌胃4周,以开同为阳性对照药,观察Scr、BUN、24hUpr(24h尿蛋白)、ALB、Hb、胰岛素样生长因子-1(IGF-1)水平的变化,进行光镜(HE、PAS染色),透射电镜以及免疫荧光观察肾组织病理学改变。结果与模型组比较,肾衰养真胶囊组大鼠的肾组织病理形态明显改善,肾衰养真胶囊可降低Scr、BUN、24hUpr,升高ALB、Hb、IGF-1。结论肾衰养真胶囊可显著减轻CRF营养不良模型大鼠肾组织病理学改变,改善肾功能及营养状况。
Objective To investigate the renoprotection of Shenshuai Yangzhen（SSYZ） capsule, a preparation of traditional Chinese medicine, in malnutrition rats with chronic renal failure （CRF）. Methods Rat CRF malnutrition model was created by feeding 0.5 % adenine and 4 % caseinum. Rats developed malnutrition were randomized into model group, Ketosteril group, SSYZ capsule group,and normal control group. After 4 weeks of treatment, blood urea nitrogen （BUN） , serum creatinine （ Scr）, serum albumin （ ALB）, insulin like growth factor - 1 （ IGF - 1 ） , hemoglobin （Hb） and 24 hour urinary protein excretion （24hUpr） were determined. Kidney tissue was examined by microscope （ included HE and PAS）, electron microscope and immunofluorescence. Results Malnutrition began at the end of 8 weeks in CRF rats. Compared with those in the model group, the plasma BUN and Scr and 24hUpro in SSYZ capsule group were signifi- cantly lower and plasma ALB, IGF - 1 and Hb were significantly higher. Pathology of SSYZ capsule group was significant- ly meliorated after treatment with SSYZ capsule. Coulusion SSYZ capsule has a possible therapeutic effect in improving malnutrition and reducing renal damage in rats with renal insufficiency.
出处
《广东医学》
CAS
CSCD
北大核心
2008年第9期1434-1437,共4页
Guangdong Medical Journal
基金
国家自然科学基金(编号:30672768)
广东省自然科学基金(编号:06024428)
广州市科技基金(编号:2006Z3-E5051-1)
南方医科大学开发基金(编号:200601)
珠江医院院长基金(编号:200302)
关键词
肾衰养真胶囊
慢性肾衰竭
营养不良
Capsule of Shenshuai Yangzhen Chronic renal failure Malnutrition
