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肝移植术后激素应用方案的变迁 被引量：3

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摘要 在近半个世纪的肝移植临床实践中，糖皮质激素（以下称激素）作为术后最常用的主流免疫抑制剂之一，在排斥反应的预防与治疗中占据极其重要的地位。然而，随着临床经验的积累，尤其是长期生存者的增多，人们发现肝移植术后长期应用激素具有一些严重的并发症，如高血压、骨质疏松、生长迟缓等。
作者 何晓顺 胡安斌
机构地区 中山大学附属第一医院器官移植中心
出处 《中华外科杂志》 CAS CSCD 北大核心 2008年第15期1123-1125,共3页 Chinese Journal of Surgery
关键词 肝移植术后 激素应用 变迁 免疫抑制剂 糖皮质激素 长期生存者 临床实践 排斥反应
分类号 R686 [医药卫生—骨科学]
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参考文献22

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同被引文献25

  • 1Llado L,Xiol X,Fiquerns J,et al.Immunosuppression without steroids in liver transplantation is safe and reduces infection and metabolic complications:results from a prospective multicentor randomized study.J Hepatol,2006,44:710-716.
  • 2Liu CL,Fan ST,Lo CM,et al.Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after livertransplantation:a protocol with early elimination of steroids and reduction of tacrolimus dosage,liver Transpl,2004,10:728-733.
  • 3Toyoki Y,Hakamada K,Narumi S,et al.Primary immunosuppression regimen of rapid steroid withdrawal after living related liver transplantation:a single center experience.Transplant Proc,2004,36:2279-2281.
  • 4Innoeenti F,Hepp J,Humeres R,et al.Rapid steroid taper and neoral monotherapy in liver transplantation in Chile:a step in the right direction? Transplant Proc,2004,36:1675-1676.
  • 5Marubashi S,Dono K,Amano K,et al.Steroid-flee living-donor liver transplantation in adults.Transplantation,2005,80:704-706.
  • 6Ringe B,Braun F,Schutz E,et al.A novel management strategy of steroid-free immunosuppression after liver transplantation:efficacy and safety of tacrolimus and mycophenolate mofetil.Transplantation,2001,71:508-515.
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  • 8Davidson J, Wilkinson A, Dantal J, et al. New-onset diabetes after transplantation : 2003 international eonsensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation ,2003,75 : SS3-SS24.
  • 9Greig P, Lilly L, Seudamore C, et al. Early steroid withdrawal after liver transplantation : the Canadian tacrolimus microemulsion cyclosporin A trial : 1 -year follow-up. Liver Transpl, 2003,9:587-595.
  • 10Matinlauri II-I, Nurminen MM, Hockerstedt KA, et al. Changes in liver graft rejections over time. Transplant Proc, 2006,38 : 2663- 2669.

引证文献3

二级引证文献9

中华外科杂志
2008年 第15期

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