摘要
应用地塞米松抑制试验对14例 I 型精神分裂症患者进行下丘脑-垂体-肾上腺轴功能评价,并将其与症状学进行相关分析。结果发现①8:00 AM 基础血浆皮质醇水平与行为紊乱呈正相关,②11:00PM 皮质醇水平与阳性症状总分呈负相关,③.4:00 PM 皮质醇相对变化率与妄想呈正相关。这些结果支持 HPA 功能与阻性症状的正相关。本文针对这种关系的几种可能性进行了讨论。
We assessed HPA-function by Dexamotasone Supression Test(DST)and analysised correlation be- tween DST results and symptomology in 14 patients with type Ⅰschizophrenia. We found:①8:00 AM basic plasma cortisol concentration correlated positively with bizzare behavior. ②11:00 PM plas- ma cortisol concetration correlated negatively with total scale of SAPS.③4:00 PM rate of cortisol rel- atively changed correlated positively with delusion. The results supported positive correlation between HPA-function and positive symptoms. The possibility for correlation was discussed.
关键词
精神分裂症
下丘脑
垂体
肾上腺
schizophrenia
hypothalamo-hypophyseal system/AN
pituitary-adrenal system/AN
