摘要
目的:通过对肥大心肌组织中AngⅡ含量的对比分析,探索中药丹芪葛酮逆转心肌肥厚的机理。方法:自发性高血压大鼠(SHR)24只,随机分为生理盐水组(NG);卡托普利组(CAP);丹芪葛酮组(DGH),每组各8只,另设立正常的Wister大鼠为对照组(CG)。于连续用药8周后取材,测定全心重/体重(HW/BW)、左室重/体重,心肌血管紧张素Ⅱ(AngⅡ)和内皮素(ET)含量。结果:丹芪葛酮组使左心指数降低,与NG相比P<0.05。丹芪葛酮组左心室AngⅡ、ET与NG组相比表达下降(P<0.05)。结论:丹芪葛酮组方具有通过降低大鼠心肌AngⅡ含量而达到逆转心肌肥厚的作用。
This is a comparative study of Ang Ⅱ contents in hypertrophia myocardium tissues, in an attempt to understand the mechanisms of reversing myocardial hypertrophy. In the study, twenty-four spontaneous hypertensive rats （SHR） were randomly divided into three groups （each=8）： a normal sodium group （NG）, a captopril group（CAP）, and a DanQiGeTong group （DGH）. A normal control group （normal Wister rat CG） was also created. Heart weight/body weight （HW/BW）, left-ventricle weight/ body weight （lvw/bw）, and levels of Angiotensin Ⅱ and ET in ventricular muscle were measured 8 weeks after the successive medication. Study results show that the DanQiGeTong group has registered a reduced left cardiac index, compared with NG （P〈0.05）, after treatment. Apparently, DanQiGeTong is able to produce an effect on reversing myocardial hypertrophy through lowering down Ang Ⅱ of myocardium.
出处
《世界科学技术-中医药现代化》
2008年第3期48-51,共4页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
安徽省教委自然科学基金项目(2005kj265):丹芪葛酮逆转心肌肥厚的前瞻性研究
