2Shimonov M, Hayat H, Chaitchik S, et al. Combined systemic chronotherdpy and hepatic artery infusion for the treatment of metastatic colorectal cancer confined to the liver [J]. Chemotherapy, 2005,51(2/3) :111-115.
4Hrushesky WJ. The clinical application of chronobiology oncology[J]. Am J Anatomy, 1983,168(4) : 519-542.
5Harris BE, Song R, Soong SJ, et al. Relationship between dihydropyrimidine dehydrogenase activity and plasma 5- fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion[J]. Cancer Res, 1990,50(1) :197-201.
6Falcone A, Allegrini G, Antonuzzo A, et al, Infusion of fluorouracil ang leucovorin: Effect of timing and semi- intermittency of drug delivery[J], Ontology, 1999,57(3) : 195- 201.
8Hrushesky WJ,Langevin T,Kim YJ, et al. Circadian dynamics of tumor necrosis factor alpha (cachectin)[J]. J Exp Med,1994,180(3):1059-1065.
9Iacobelli S, Garufi C, Irtelli L, et al. A phase Ⅰ study of recombinant interferon-alpha administered as a seven-day continuous venous infusion at circadian-rhythm modulated rate in patients with cancer[J]. Am J Clin Oncol, 1995,18 (1) : 27- 31.
10Focan C. Circadian rhythms and cancer chemotherapy[J]. Pharmacol Ther, 1995,67(1) : 1-52.
3Moore RY, Eichler VB. Central neural mechanisms in diurnal rhythm regulation and neuroendocfine responses to light [J]. Psychoneuroendocrinology, 1976,1(3) :265 - 279.
4Mormont MC, Levi F. Circadian- system alterations during cancer processes: a review[ J]. Int J Cancer, 1997,70(2) ;241 - 247.
5Mormont MC, Bleuzen P, Waterhouse J, et al. Marked 24 h rest/activity rhythms are associated with better quality of life, better response and longer survival in patients with metastatic colorectal cancer and good performance status[J]. Clin Cancer Res, 2000,6(8) : 3038 - 3045.
6Levi F. Chronophannacology of anticancer agents [A]// Redfem P,Lenaner B. Physiology and pharmacology of biological rhythms, Berlin :Springer-Verlag, 1997:299 - 331.
7Granda TG, L6vi F. Tumor - based rhythms of anticancer efficacy in experimental models[J]. Chronobiol lnt, 200'2, 19(1) :21 - 41.
8Tampellini M, Filipski E, Liu XH, et al. Doeetaxel chronophannocology in mice[J]. Cancer Res, 1998,58(17) :3896 - 3904.
9Granda TG, D' Attino RM, Filipski E, et al, Circadian optimization of ifinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma[J]. Br J Cancer,2002,86(6) :999 - 1005.
10Smaaland R, Sothem RB, Lote K, et al. Rhythms ia human bone marrow and blood cells [J]. Chronobiol Int,2002,19(1) : 101 - 127.
