摘要
目的：探讨黄芪生脉散对急性心肌梗塞（ＡＭＩ）气虚血瘀、气滞血瘀型患者溶栓治疗的临床疗效的影响。方法：采用黄芪生脉散结合尿激酶（ＵＫ）溶栓治疗ＡＭＩ患者２２例（治疗组），并与２０例单用ＵＫ溶栓治疗者作对照（对照组）。结果：治疗组冠脉再通率为７２．７％，对照组冠脉再通率为６５．０％（Ｐ＞０．０５）；治疗组胸痛发生率１３．６％，对照组胸痛发生率５０．０％（Ｐ＜０．０５）。实验室检查示：治疗组治疗后动脉血氧分压（ＰａＯ２）、动脉血氧饱和度（ＳａＯ２）水平均明显升高（Ｐ均＜０．００１）；血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ）水平均明显降低（Ｐ均＜０．００１）；全血粘度（ηｂ）、血浆粘度（ηｐ）水平均明显降低（Ｐ均＜０．０１）；与对照组比较均有显著性差异（Ｐ均＜０．０５）。结论：黄芪生脉散对气虚血瘀、气滞血瘀型ＡＭＩ患者ＵＫ溶栓治疗疗效有增强作用，并可改善心肌供血，防治胸痛和缓解机体应激状态等。
Objective:To research the therapeutic efficacy of “huang qi sheng mai” powder on acute myocardial infarction (AMI) with“energy deficit and blood stasis ” and “energy stagnation and blood stasis” type.Methods:Twentytwo cases of AMI were treated with “huang qi sheng mai” powder combined use of thrombolytic agent (urokinase, UK)(treatment group) and compared to 20 cases of AMI treated with UK alone.Results:The coronary artery recana lization rates were 72 7% and 65 0% in treatment group and control group respectively ( P >0 05).The attack rates of angina were 13 6% and 50 0% in treatment group and control group respectively ( P <0 05).In treatment group,the partial pressure of oxygen in artery (PaO 2) and arterial oxygen saturation (SaO 2) level were raised significantly (all P <0 001),the plasma renin activity (PRA) and angiotensine Ⅱ level were decreased obviously (all P <0 001),the whole blood viscosity and plasma viscosity were decreased obviously (all P <0 01),they had an obvious difference between two groups(all P <0 05).Conclusions:“huang qi sheng mai” powder can enhance thrombolytic action of UK,improve myocardial ischemia,prevent angina attack and relieve stress reaction in treatment of AMI with “energy deficit and blood stasis” and “energy stagnation and blood stasis” type.
关键词
黄芪生脉散
心肌梗塞
溶栓疗法
尿激酶
huang qi sheng mai” powder acute myocardial infarction blood stasis thrombolytic treatment
