摘要
为探讨心钠素（ANP）对急性肾功能衰竭的治疗作用，用阻断肾动脉建立了实验性兔缺血性急性功能衰竭模型，并应用ANP治疗。治疗结果表明：与对照组相比较，肾小球滤过率6.02±0．75VS2.05±1．05ml／min，尿量381.67±217.75VS23.20±9．35μl／min，P值均＜0001。提示心钠素可有效改善急性肾功能衰竭的肾功能。
In order to confirm the effect of atrial natriuretic peptide (ANP) on acute renal failure, animal model of ischemic acute renal failure (ARF) was made in rabbits by renal artery occlusion. After the procedure, the rabbits were given ANP.Glomerular filtration rate (GFR) and uring flow rate were higher in treatment group compared to the control group (6. 02±0. 75vs 2. 05±1. 05ml/min and 381. 67±219. 75vs 23. 20±9. 35ul/min, both P< 0. 001). It was suggested that ANP had a favorable influence for improvement of renal function inARF.
