摘要
目的探讨细胞因子的动态水平在病毒性心肌炎各期的临床价值。方法采用放免法、化学比色法及酶联免疫法检测31例病毒性心肌炎患者和32例正常人的血清肿瘤坏死因子(TNF-a)、一氧化氮(NO)、白细胞介素-2,6(IL-2,IL-6)的动态水平。结果四种细胞因子的血清水平在病毒性心肌炎组均明显高于正常对照组,并呈急性期>亚急性期>恢复期。结论肿瘤坏死因子-a和一氧化氮、白介素均参与病毒性心肌炎的心肌细胞炎性损伤过程,其浓度变化可能具有双重作用。
Objective To explore the clinical value of dynamic change of serum cytokines levels in patients with virus myocarditis.Methods The serum levels of tumor necrosis factor（TNF-a）,nitric oxide（NO）, interleukin-2,6（IL-2,IL-6） from 31 patients with virus myocarditis and 32 of healthy people were studied by radioimmunoassay and colorimetricochemical method, enzyme-linked immunossorbent assay.Results The serum levels of TNF-a,IL-2,IL-6,NO were remarkly higher than that of normal group, they had significant difference in various periods in patients with virus myocarditis ,and correlated with the severety of virus myocarditis. Conclusion Cytokines take part in the occurrence and development of virus myocarditis.
出处
《中国现代医药杂志》
2008年第7期50-52,共3页
Modern Medicine Journal of China
