摘要
目的研究青少年神经性厌食患者治疗前后瘦素和类胰岛素生长因子1（IGF-Ⅰ）浓度的变化。方法检测11例青少年神经性厌食患者治疗前后的血清瘦素和IGF-Ⅰ浓度，测量身高和体质量，计算体重指数，比较治疗前后血清瘦素和IGF-Ⅰ浓度的变化，并与11例同年龄的健康儿童进行比较。结果（1）青少年神经性厌食患者血清瘦素和IGF-Ⅰ浓度治疗有效后3个月较治疗前显著增高（P〈0．01），但都明显低于正常对照组（P〈0．01）；（2）无论是正常者还是治疗前和治疗后瘦素和IGF-Ⅰ浓度均与体重指数（BMI）呈显著正相关（P〈0．01）；（3）无论是正常者还是治疗前和治疗后瘦素与IGF-Ⅰ均呈显著正相关（P〈0．01）。结论青少年神经性厌食患者体内瘦素和IGF-Ⅰ浓度在治疗有效前后发生了明显的变化，这种变化与神经性厌食患者脂肪含量的变化相一致。
Objective To study the changes of leptin and insulin-like growth factor- Ⅰ （IGF-Ⅰ ） in adolescents with anorexia nervosa（AN） before and after three months of therapy. Methods The plasma levels of leptin and IGF- Ⅰ were measured in 11 adolescents with AN before and after three months of therapy and 11 normal adolescents of the same age, and their height, weight were examined and their body mass index （BMI） was calculated, and the results were compared before and after therapy, and were compared with those from age-matched normal adolescents respectively. Results （ 1 ） The plasma levels of leptin and IGF- Ⅰ , as well as the BMI in the AN patients after three months of therapy were significantly higher than those before the therapy, and both were significantly lower than those in the controls. （2）Significant correlations between the plasma leptin levels and IGF- Ⅰ and BMI were detected in the AN patients both before and after the therapy, as well as in the controls. （3）Significant correlations between the plasma leptin levels and IGF- Ⅰ were detected in the AN patients both before and after the therapy, as well as in the controls. Conclusion The plasma levels of leptin and IGF- Ⅰ resulted in significant changes, and these changes were consistent with body fat content in adolescents with AN.
出处
《中国基层医药》
CAS
2008年第6期921-922,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
瘦素
类胰岛素生长因子
厌食
神经性
青少年
Leptin
lnsulin-like growth factor-Ⅰ
Anorexia nervosa
Adolescents
