摘要
目的评价曲美他嗪（TMZ）和美托洛尔（Metoprolol）与其他常规药物相结合治疗伴有2型糖尿病的稳定型心绞痛患者的疗效。方法78例2型糖尿病且至少有2个月以上的稳定的、可由劳累诱发的心绞痛病史的患者人选试验。患者随机分成两组，一组给予曲美他嗪20mg，每日3次；另一组给予美托洛尔25mg，每日2次。两组均联合使用巴米尔、钙通道拮抗剂和长效硝酸酯类及常规降糖、降脂药物治疗10周，对疗效进行统计学分析，同时观测心率、血压、血糖、血脂的变化。结果两组患者治疗后心绞痛发作次数、持续时间及硝酸甘油消耗量明显降低，而至下一次心绞痛发作的时间及射血分数明显增加，两者疗效差异无统计学意义（P〉0．05），而治疗前后心率、血压、血糖及血脂，曲美他嗪组差异无统计学意义（P〉0．05），美托洛尔组差异有统计学意义（P〈0．05，P〈0．01），但两组比较差异有统计学意义（P〈0．05）。结论曲美他嗪与其他药物联合治疗对伴2型糖尿病的稳定型心绞痛患者有效且安全。
Objective To evaluate the effect of trimetazidine（TMZ） and metoprolol combining the other regular medicine on the stable angina pectoris patients with type 2 diabetes mellitus. Methods 78 patients with type 2 diabetes mellitus and the patients with no less than two months stable and revoked-angina pectoris by effort were collected. They were divided into two groups. In one group,20mg of TMZ was used three times a day. In the other group,25mg metoprolol was used and two times a day. The two groups all combined with the regular medicine, bamyl, calciume-antagonist and long-efficency nitrate and rutine antilipemic, antidiabetic agents for ten weeks and analyzed the statistical difference of two groups. Meanwhile some parameter were observed including the heart rate, blood pressure,blood glucose, TG, TC, HDL-C and LDL-C during the treatment. Results In two groups, cardiac pectoris frequency and lasting-time and the used-nitroglycerin decreased significantly, while the time of next angina outcome and left ventricular ejection fraction（EF% ） increased significantly. The therapy hasen＇t great difference（P 〉0.05） in two groups. But in TMZ group, HR, bllod pressure, blood glucose and blood fat haven＇t great difference （ P 〉 0.05） before ad after thereapy. In metoprolol group the difference is significant（ P 〈 0.05, P 〈 0.01 ） and two groups have great difference（P 〈 0.05）. Conclusion The results suggest that the TMZ is effect and safe on the sta- ble angina pectoris patients with type 2 diabetes mellitus.
出处
《中国基层医药》
CAS
2008年第6期889-890,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
曲美他嗪
美托洛尔
糖尿病
2型
心绞痛
稳定型
Trinetazidine
Metoprolol
Diabetes mellitus, type 2
Angina pectoris,stable- type
