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脑红蛋白在人体组织细胞的定位分布及意义 被引量：24

Study on the Distribution and Location of Neuroglobin in Human Tissues and Cells
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摘要 目的探讨脑红蛋白(NGB)在人体组织细胞的定位分布及其意义。方法用免疫组织化学SP法检测NGB在人体不同组织细胞的分布和定位。结果NGB主要分布在人体中枢神经系统和周围神经系统的神经细胞内,在某些内分泌组织和生殖系统亦有分布。NGB免疫反应阳性物质主要定位于细胞质中。结论NGB在人体神经组织、内分泌组织和生殖系统的表达提示NGB对这些组织的氧利用及功能活动有重要作用。 Objective To explore the distribution and location of neuroglobin（NGB）and its function in human tissues and cells.Methods The distribution and localization of NGB in human tissues and cells were examined by immunohistochemical method.Results NGB-positive cells were mainly distributed in neurons of central nervous system and peripheral nervous system,and some in endocrine tissues and genital system.NGB-immunoreactive product located in the cytoplasm of these cells.Conclusion The expression of NGB in human nervous tissues,some endocrine tissues and genital system suggested that NGB might play an important role in the utilizations of oxygen and physiological functions.
作者 秦豪杰 张录顺 武娜 郭亚东 张林 李明远 官鹏
机构地区 四川大学华西基础医学与法医学院法医病理学教研室
出处 《四川大学学报（医学版）》 CAS CSCD 北大核心 2008年第4期609-611,共3页 Journal of Sichuan University(Medical Sciences)
基金 四川省应用基础研究计划项目基金(No.05JY029-020) 四川大学科技创新基金(2004CF08)资助
关键词 脑红蛋白 免疫组织化学 人体组织 Neuroglobin Immunohistochemistry Human tissues
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

  • 1Burmester T, Weich B, Reinhardt S, et al. A vertebrate globin expressed in the brain. Nature,2000; 407 (6803) : 520- 523.
  • 2Pesee A, Bolognesi M, Boeedi A, et al. Neuroglobin and cytoglobin,fresh blood for the vertebrate globln family. EMBO Reports,2002;3(12):1146-1151.
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  • 4杜显刚,官鹏,陈雪梅,张林,谭志巍,王亚琴,Yun juan Sun.脑红蛋白在大鼠体内的分布[J].中国法医学杂志,2005,20(5):260-262. 被引量：6
  • 5Zhang CG, Wang CL, Deng MY, et al. Full-length eDNA cloning of human neuroglobin and tissue expression of rat neuroglobln. Bioehem Biophys Res Commun, 2002 ; 290 (5) : 1411-1419.
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  • 10杜显刚,官鹏,陈雪梅,张林,李明远,谭志巍,王亚琴,Yunjuan Sun.大鼠脑外伤后大脑皮质脑红蛋白的定量研究[J].中国法医学杂志,2006,21(3):129-132. 被引量：17

二级参考文献29

  • 1尚爱加,周定标,王利红,张成岗.沙鼠脑缺血再灌注损伤后血清脑红蛋白变化[J].中华医学杂志,2005,85(28):2003-2005. 被引量：7
  • 2Burmester T, Weich B, Reinhardt S, et al. A vertebrate globin expressed in the brain[J]. Nature, 2000, 407:520-523.
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  • 7Schmidt M, Giessl A, Laufs T, et al. How does the eye breathe - evidence for the Neuroglobin - mediated oxygen supply in the mammalian retina[ J ]. J Biol Chem, 2003,278(3): 1932 - 1935.
  • 8Burmester T, Weich B, Reinhardt S, et al. A vertebrate globin expressed in the brain [J]. Nature, 2000, 407(6803) : 520 - 523.
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  • 10Conti A C, Raghupathi R, Trojanowski J Q, et al. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post - traumatic period [J]. J Neurosci, 1998, 18(15) :5663 -5672.

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四川大学学报（医学版）
2008年 第4期

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