摘要
目的:探讨阿立哌唑与氯丙嗪对女性精神分裂症患者疗效及不良反应的差异。方法:将100例女性精神分裂症患者,随机分为两组各50例,治疗8周,采用对照、开放性研究,以阳性与阴性症状量表(PANSS)、不良反应量表(TESS)评定临床疗效及不良反应。同时检测血糖、催乳素等生化指标。结果:治疗8周末阿立哌唑组显效率84%,有效率96%,氯丙嗪组分别为80%和90%,两组差异无显著性(χ2=0.271,1.382;P均>0.05),阿立哌唑与氯丙嗪的总体疗效相当。氯丙嗪较阿立哌唑引起肌强直、震颤、扭转痉挛、静坐不能等锥体外系副反应发生率高,引起胆碱能不良反应如口干、视物模糊、便秘、鼻塞等发生率高(P<0.05);阿立哌唑对催乳素水平无明显影响,对血糖、体重影响较氯丙嗪小(P<0.05)。结论:阿立哌唑对女性精神分裂症疗效与氯丙嗪相当,安全性高,依从性好,副作用小。
Objective： To explore the differences of therapeutic effects and adverse effects between aripiprazole and chloropromazine. Methods： 100 female schizophrenia were randomly divided into aripirazole and chloropromazine group for 8w. By using mlticentre, open, random-control method, to messure therapeutic effect by PANSS,to messure adverse effects by TESS. Results： At the end of 8 th week, excellence and effective rates were 80% and 90% in the aripiprazole and 84% and 96% in the chlorpromazine, which showed no significant the incidence rate of cholinergic adverse effects is too（P〈0.05）, aripiprazole have no effects on P RL, and less effects on blood glucose and weight than chloropromazine （P〈0.05）. Conclusion： Aripiprazole is equivalent to chloropromazine and higher safety better compliance and less side effects in female chlorolpromazine.
出处
《中国民康医学》
2008年第14期1562-1563,1590,共3页
Medical Journal of Chinese People’s Health
关键词
阿立哌唑
氯丙嗪
精神分裂症
疗效
A ripiprazole
Chloropromazine
Schizophrenia
Curative effect
