摘要
目的：探讨脑膜瘤立体定向放射外科（ＳＲＳ）治疗后细胞增殖活性变化情况。方法：以９例曾行ＳＲＳ治疗的脑膜瘤手术标本为研究材料，选取同期年龄相近，病理亚型相同，未行ＳＲＳ治疗的脑膜瘤标本为对照组，采用免疫组织化学染色方法，检测肿瘤增殖细胞核抗原（ＰＣＮＡ）标记指数（ＰＣＮＡＬＩ）值。结果：ＳＲＳ治疗组ＰＣＮＡＬＩ为０～４．４％（２．０±１．５％），未治疗组为２～２８．９％（８．１±８３．％），Ｐ＜０．０５。结论：放射外科治疗后脑膜瘤细胞增殖能力明显下降。
?Purpose To investigate the effect of stereotactic radiosurgery(SRS) on the proliferation of meningiona cells. Methods 18 paraffin sections of meningiomas, including 9 SRS-treated (SRS group) and 9 non-SRS-treated meningiomas(control group) at the same period, with same pathological subtype, were examined for expression of proliferating cell nuclear antigen(PCNA). Result The PCNA labeling indices(LI) of SRS group were 0～4.4% (2.0±1.5%), and the one of control group 2～28.9%(8.1±8.3%), P<0.05. Conclusion SRS can significantly inhibit proliferation of meningiona cells.
关键词
立体定向
放射外科
脑膜瘤
增殖细胞核抗原
Stereotactic radiosurgery, Meningioma, Proliferating cell nuclear antigen
