细胞色素P450 3 A亚族参与的药物代谢及其异常表达的意义
摘要
细胞色素P450（cytochrome P450，CYP450）是广泛存在于生物体内的一类含血红蛋白和硫羟基的蛋白，是体内代谢转换的主要酶系。CYP450存在于人体细胞的微粒体中，主要是肝细胞。CYP450的蛋白编码有55个基因，29个是假基因（psuedogene）。CYP450有许多亚族，其中最主要是CYP4503A亚族（CYP3A），占肝细胞CYP450的30％～60％。
出处
《上海医学》
CAS
CSCD
北大核心
2008年第6期452-454,共3页
Shanghai Medical Journal
参考文献13
-
1Yamaori S, Yamazaki H, Iwano S, et al. Ethnic differences between Japanese and Caucasians in the expression levels of mRNAs for CYP3A4, CYP3A5 and CYP3AT: lack of co-regulation of the expression of CYP3A in Japanese livers. Xenobiotica, 2005, 35:69-83.
-
2Huang W, I.in Y S, McConn D J 2nd, et al. Evidence of significant contribution from CYP3A5 to hepatic drug metabolism. Drug Metab Dispos, 2004, 32: 1434-1445.
-
3Wang A, Yu B N, Luo C H, et al. Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients. Eur J Clin Pharmacol, 2005, 60: 843-848.
-
4Lamba J K, Lin Y S, Schuetz E G, et al. Genetic contribution to variable human CYP3A-mediated metabolism. Adv Drug Deliv Rev, 2002, 54: 1271-1294.
-
5Kim K A, Park P W, Lee O J, et al. Effect of CYP3A5 * 3 genotype on the pharmacokinetics and pharmacodynamics of amlodipine in healthy Korean subjects. Clin Pharmacol Ther, 2006, 80: 646-656.
-
6Schilthuizen C, Broyl A, van der Holt B, et al. Influence of genetic polymorphisms in CYP3A4, CYP3A5, GSTP1, GSTM1, GSTT1 and MDR1 genes on survival and therapy- related toxicity in multiple myeloma. Haematologica, 2007, 92: 277-278.
-
7Dhaini H R, Thomas D G, Giordano T J, et al. Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. J Clin Oncol, 2003, 21: 2481-2485.
-
8Leskela S, Honrado E, Montero-Conde C, et al. Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer. Endocr Relat Cancer, 2007, 14: 645-654.
-
9Bangsi D, Zhou J, Sun Y, et al. Impact of a genetic variant in CYP3A4 on risk and clinical presentation of prostate cancer among white and African-American men. Urol Oncol, 2006, 24, 21-27.
-
10Keshava C, McCanlies E C, Weston A. CYP3A4 polymorphisms- potential risk factors for breast and prostate cancer: a HuGE review. Am J Epidemiol, 2004, 160: 825-841.
-
1刘卉,陈俊抛,平井圭一.被促衰老P_8型小鼠肝细胞色素P4503A对学习与记忆的影响[J].第一军医大学学报,1999,19(4):321-322. 被引量：1
-
2刘卉,陈俊抛,平井圭一.SAM肝细胞色素P450 3A对衰老的作用[J].癌变·畸变·突变,1999,11(5):219-221.
-
3刘彦,王寅,朱正美,崔肇春.脂多糖增加小鼠巨噬细胞多磷酸肌醇脂代谢转换[J].中国生物化学与分子生物学报,1998,14(3):289-294. 被引量：2
-
4杨静,彭仁琇,等.大鼠肝微粒体细胞色素P450 3A参与甘草次酸代谢[J].中国药理学会通讯,2000,17(3):37-38.
-
5刘卉,陈俊抛,平井圭一.肝细胞色素P450 3A在衰老加速鼠中的作用[J].广州医药,1999,30(5):3-6.
-
6陆红玲,钱民章.橙皮苷对辛伐他汀调脂作用及细胞色素P4503A mRNA表达的影响[J].中国药理学通报,2004,20(3):330-334. 被引量：6
-
7孙捷.柑橘果实对人细胞色素P_(450)3A(CYP3A)活性的抑制作用[J].国外医学（中医中药分册）,2004,26(4):236-236.
-
8古赛,姜蓉.枸杞多糖对酒精性脂肪肝大鼠肝细胞色素P4503A的影响[J].重庆医科大学学报,2007,32(4):371-375. 被引量：11
-
9李敏,张冰,刘小青.基于L02细胞CYP3A变化的辛热药附子、仙茅药性表达研究[J].中华中医药杂志,2010,25(12):2351-2355. 被引量：8
-
10陈磊.治疗脸色发黄的偏方[J].中华养生保健,2011(4):63-63.
