摘要
目的:探讨胃肠道黏膜相关淋巴组织(MALT)淋巴瘤的临床病理特点以及bcl-10和bcl-2蛋白在MALT淋巴瘤中表达的意义。方法:对46例胃肠MALT淋巴瘤进行临床病理分析,运用免疫组织化学方法检测bcl-10和bcl-2在肿瘤中的表达。结果:46例MALT淋巴瘤男女发病之比为1.87:1,平均年龄53岁。组织学以单核样B细胞克隆性增生为主,伴淋巴上皮病变,少数有大细胞转化。免疫组化bcl-10在不同临床分期,恶性度及复发转移组中胞核阳性的表达率分别为28.13%,70%,75%;72.5%,83.3%;33.33%,71.4%。其表达均存在显著性差异(P<0.05)。bcl-2在各组中的阳性表达率分别为53.13%,60%,50%;77.5%,50%;77.78%,46.43%。除不同临床分期组外(P>0.05),其表达均存在显著性差异(P<0.05)。结论:胃肠道MALT淋巴瘤是一种低度恶性淋巴瘤,具有特殊的病理组织学形态。MALT淋巴瘤中bcl-10胞核及bcl-2的表达对于肿瘤的发生发展以及复发转移有着重要的意义。
Objective： To investigate the clinicopathological features of the gastrointestinal mucosal associated lymphoid tissue （MALT） lymphoma and the significance of expression of bcl - 10 and bcl - 2 protein in gastrointestinal MALT lymphoma. Methods：The clinicopathological features of the gastrointestinal MALT lymphoma were analyzed and immunohistochemistry EnVision method was used to test the expression of bcl - 10 and bcl - 2. Results ： The male ： female ratio of 46 cases was 1.87 ： 1 and the mean age was 53 years. Microscopically, clonal proliferation of monocytoid B -cells were the main changes usually accompanied with lymphoepithelial lesions and transformation to large cells was occasionally present, bcl - 10 expressed on the nuclei of tumor cells in different clinical stage groups, degree of malignancy groups and relapse or metastases groups of gastrointestinal MALT lymphoma （28.13% ,70%, 75% ;72.5% ,83.3% ;33.33% ,71.4% ） and the expression was significantly different among every group （P 〈 0.05）. Similarly, bcl -2 was also positive in every group of gastrointestinal MALT lymphoma （53.13%, 60%, 50%, 7＂7.5%, 50%, 7＂7.78%, 46.43% ） and the expression was significantly different among each group （P 〈 0.05 ） except the clinical stage groups （ P 〉 0.05 ）. Conclusion： Gastrointestinal MALT lymphoma is a low malignancy lymphoma with specific histological features. Positive nuclear expression of bcl - 10 and positive expression of bcl - 2 may play an important role in the pathogenesis, development and relapse or metastases of gastrointestinal MALT lymphoma.
出处
《现代肿瘤医学》
CAS
2008年第7期1178-1182,共5页
Journal of Modern Oncology
