摘要
目的:研究莫西沙星治疗社区获得性下呼吸道感染老年患者的耐受性和安全性。方法:将197例社区获得性下呼吸道感染老年患者纳入研究,其中男性104例,女性93例,平均年龄(73±11)岁。患者静脉给予莫西沙星400mg/d,7～10d,继口服莫西沙星400mg/d,3～6d。疗程约2周。观察莫西沙星治疗的耐受性和不良反应。结果:197例患者中194例完成2周治疗,有3例因出现神经精神不良反应和皮疹中断治疗。194例中痊愈135例,显效42例,进步17例;出现不良反应24例,主要为轻度的神经精神及消化系统不良反应。结论:莫西沙星是治疗社区获得性下呼吸道感染较为有效和安全的药物,老年患者能良好耐受。
Objective： To study the tolerance and safety of moxifloxacin in the treatment of elderly patients with comamnityacquired lower respiratory tract infections. Methods： One hundred and ninety-seven patients with community-acquired lower respirator）＇ tract infections [ 104 men, 93 women, average age （73 ± 11 ） years] were included in the study. They received IV moxifloxacin 400 mg/d for 7 - 10 days, followed by oral moxifloxacin 400 mg/d for 3 - 6 days. The duration of treatment was about 2 weeks. The tolerance and safety of moxifloxacin were observed. Results： Two-week therapy was accomplished in 194 patients, and the therapy was discontinued in 3 patients because of neuropsychic disorders and rash. Of the 194 patients, 135 cured perfectly, 42 improved significantly, and 17 improved. The adverse reactions occurred in 24 patients, and the main reactions were mild neuropsychic and gastrointestinal disorders. Conclusion： Moxifloxacin is a relatively effective and safe agent for treating community-acquired lower respiratory tract infections. It is well tolerated to elderly patients.
出处
《药物不良反应杂志》
2008年第3期168-172,共5页
Adverse Drug Reactions Journal
关键词
莫西沙星
社区获得性下呼吸道感染
老年
耐受性
安全性
moxifloxacin
community-acquired lower respiratory tract infection
elderly
tolerance
safety
