期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

细胞凋亡在非酒精性脂肪性肝炎发病机制中的作用 被引量：2

暂未订购
导出
摘要 非酒精性脂肪性肝病（NAFLD）包括了肝脏损伤的一个广泛的疾病谱：从单纯性脂肪肝到非酒精性脂肪性肝炎（NASH），继之可进展为肝硬化和终末期肝病。单纯性脂肪肝是一种良性少进展的病变，仅以肝细胞脂肪变性为主要病理改变，NASH则表现为在没有明确饮酒史的患者中出现类似酒精性脂肪性肝炎的病理改变，除了表现为肝细胞脂肪变性外还表现为炎症反应，伴有或不伴有纤维化，它是NAFLD疾病谱中的关键点，25％NASH患者的病情可进展为隐源性肝硬化，并发门脉高压、肝衰竭，甚至肝细胞癌。基于有些患者单纯性脂肪肝可长期保持静止状态，并不进一步发展，
作者 张静 赵景民
机构地区 军事医学科学院 解放军第三○二医院
出处 《传染病信息》 2008年第3期150-152,共3页 Infectious Disease Information
基金 中国肝炎防治基金会王宝恩肝纤维化基金(20070042/20070043)
关键词 非酒精性脂肪性肝炎 发病机制 细胞凋亡 肝细胞脂肪变性 单纯性脂肪肝 非酒精性脂肪性肝病 隐源性肝硬化 病理改变
分类号 R575.5 [医药卫生—消化系统] R735.7 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Yu AS, Keeffe EB.Nonalcoholic fatty liver disease[J].Rev Gastroenterol Disord, 2002,2 ( 1 ): 11-19.
  • 2Day CP.The natural history of NAFLD:remarkably benign in the absence of cirrhosis [J]. Gastroenterology, 2005,129 (1):375-378.
  • 3Chitturi S, Farrell GC. Etiopathogenesis of non-alcoholic steatohepatitis [J]. Semin Liver Dis, 2001,21 (1):27-41.
  • 4Feldstein AE, Canbay A, Anguol P, et al.Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis [J]. Gastroenterology,2003,125 (2): 437-443.
  • 5Galle PR, Krammer PH. CD95-induced apoptosis in human liver disease [J]. Semin Liver Dis, 1998,18(2):141-151.
  • 6Faouzi S, Burckhardt BE,Hanson JC, et al.Anti-fas induces hepatic chemokines and promotes inflammation by an NF- kappa B-independent, caspase-3-dependent pathway [J]. J Biol Chem, 2001,276(52):49077-49082.
  • 7Galle PR, Hofmann WJ, Walczak H, et al. Involvement of the CD95(APO-1/Fas) receptor a ligand in the liver damage [J]. J Exper Med, 1995,182(5):1223-1230.
  • 8Mueller M,Scaffidi C,Peters M, et al. Involvement of the CD95 system in alcohol-induced liver damage [J]. Hepatology, 1997,26(4 pt 2):270A.
  • 9Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it [J]. Mitochondrion, 2006,6(1): 1-28.
  • 10Malhi H,Bronk SF,Wemeburg NW, et al.Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis [J]. J Biol Chem ,2006,281 (17):12093-12101.

同被引文献40

  • 1Fatty Liver and Alcoholic Liver Disease Study Group of the Chinese Liver Disease Association..非酒精性脂肪性肝病诊疗指南[J].中华肝脏病杂志,2006,14(3):161-163. 被引量：1516
  • 2吴涛,季光,郑培永,柳涛.内质网应激与肝细胞凋亡[J].世界华人消化杂志,2007,15(23):2507-2515. 被引量：23
  • 3Neuschwander-Tetri BA,Caldwell SH. Nonalcohol- ic steatohepatitis: summary of an AASLD Single Topic Conference [J]. Hepatology, 2003,37 : 1202 - 1219.
  • 4Schattenberg JM, Galle PR, Schuchmann M. Apopto- sis in liver disease[J]. Liver Int, 2006,26 : 904 - 911.
  • 5Wing- Kin Syn, Steve S. Choi, Anna Mae Diehl. Ap- optosis and Cytokines in Non- Alcoholic Steatohepa- titis[J]. Clinics in Liver Disease, 2009,13 (4) .. 565 - 580.
  • 6Casey CA, Lee SM, Aziz- Seible R, et al. Impaired receptor-mediated endocytosis..its role in alcohol- induced apoptosis[J]. J Gastroenterol Hepatol,2008, 23(1) ..$46 - $49.
  • 7Scott FL,Stec B,Pop C,et al. The Fas FADD death domain complex structure unravels signalling by re- ceptor clustering[J]. Nature,2009,457 1019 - 1022.
  • 8Liyun Yuan,Neil Kaplowitz. Glutathione in liver dis- eases and hepatotoxieity[J]. Molecular Aspects of Medicine,2009,30:29 - 41.
  • 9Yuemin Nan,Rongqi Wang, Suxian Zhao, et al. Heine oxygenase- 1 prevents non- alcoholic steatohepatitisthrough suppressing hepatoeyte apoptosis inmiee[J]. Lipids in Health and Disease,2010,9 .. 124.
  • 10Sharma V, Tewari R, Sk UH, et at. Ebselen sensitizes glioblastoma ceils to tumor necrosis factor (TNFal- pha)-induced apoptosis through two distinct path- s ways involving TNF-kappaB downregulation and Fas -mediated formation of death inducing signaling complex[J]. Int J Cancer, 2008,123 (9) : 202 - 204.

引证文献2

二级引证文献15

传染病信息
2008年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部