摘要
目的研究氨力农对慢性肺心病并难治性充血性心力衰竭的治疗效果及安全性。方法60例慢性肺心病并难治性心衰患者被随机分为两组:氨力农组30例,在常规综合治疗的基础上每日加用氨力农100mg。对照组30例,继续给予氧疗、控制感染、平喘化痰、利尿及纠正酸碱失衡和电解质紊乱等常规综合治疗,疗程5d。观察治疗前后心功能及血气分析的改善情况,心脏超声检测肺动脉压力和左室射血分数,肺功能仪测定第1秒用力肺活量,并记录临床不良反应。结果两组都有确切疗效,但与对照组比较,氨力农组心功能、肺功能、血气结果的改善更加显著,肺动脉压力的下降更为明显,差异具有显著性(P<0.05)。氨力农治疗中未发现任何不良反应。结论短期应用氨力农治疗慢性肺心病并难治性心衰是安全有效的药物。
[Objective] To study the clinical effect and safety of Amrinone on patients of chronic cor pulmonale with obstinate congestive heart failure. [Methods] 60 chronic cor puhnonale patients with obstinate congestive heart failure were randomly diyided into two groups with 30 patients in each. On the basis of routine treatment, the 30 patients in Amrinone group were given 100 mg Amrinone each day for 5 days, while the patients of control group were only given the routine treatment for 5 days. The changes of cardiac function, pulmonary artery pressure（PAP）, left ventricular ejection fraction（LVEF）, blood gas analysis and FEV1 in both groups were observed before and after the treatment. Adverse reactions were also recorded. [Results] Compared with patients of the control group, patients in the treatment group had a better improvement in cardiac function, pulmonary function and blood gas analysis, as well as a more marked decline in PAP. All these mesurements had obvious difference in the two groups（P〈0.05）. No obvious adverse reaction was found in the Amrinone treatment. [Conclusion] Amrinone is effective and safe for the short-term treatment of uncompensated chronic cor pulmonale.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2008年第12期1772-1774,共3页
China Journal of Modern Medicine
关键词
氨力农
肺心病
充血性心力衰竭
Amrinone
cor pulmonale
congestive heart failure
