期刊文献+

血清胆红素与血脂及冠状动脉病变程度相关性研究 被引量:3

暂未订购
导出
摘要 目的:探讨冠心病患者血清胆红素与血脂及冠状动脉病变程度的相关性。方法:将346例冠状动脉造影患者分为冠心病组(287例)对照组(59例)。分别测定血清胆红素、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDlL-C)浓度。根据美国心脏病学会(AHA)评分标准,结合冠状动脉造影结果进行冠状动脉狭窄程度评分。观察2组病例总胆红素(TBIL)与血脂及冠状动脉狭窄程度的相关性。结果:外周血TBIL浓度冠心病组(7.6±3.2)μmol/L比对照组(12.1±3.2)μmol/L低,差异有显著性(P<0.05);TC、LDL-C浓度冠心病组(5.79±1.53)mmol/L、(5.34±1.48)mmol/L较对照组(3.82±1.15)mmol/L、(2.27±0.69)mmol/L高差异有显著性(P<0.05);HDL-C浓度冠心病组(1.11±0.57)mmol/L较对照组(1.46±0.23)mmol/L低差异有显著性(P<0.05);冠心病组TBIL与LDL-C、TC呈负相关,与HDL-C呈正相关;冠状动脉狭窄指数与TBIL、LDL-C、HDL-C有相关关系;多因素回归分析显示LDL-C及TBIL与冠状动脉狭窄指数明显相关。结论:冠心病患者TBIL水平降低;冠心病患者TBIL与TC及LDL-C有显著负相关,与HDL-C呈显著正相关;冠心病患者冠状动脉狭窄程度与TBIL及HDL-C呈负相关。
出处 《心肺血管病杂志》 CAS 2008年第4期218-220,共3页 Journal of Cardiovascular and Pulmonary Diseases
  • 相关文献

参考文献8

  • 1Troughton JA, Woodside JV, Young IS et al. Bilirubin and coronary heart disease risk in the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Eur J Cardiovasc Prev Rehabil, 2007,14:79-84.
  • 2Schwertner HA, Jackson WG, Tolan G. Associatitm of low serum concentration of bilirubin with increased risk of coronary artery disease. Clin Chem, 1994,40:18-23.
  • 3Sehwerlner HA, Fischer JR Jr. Compal ison of various lipid, lipoprotein and bilirubin combinations as risk factors for predicting comnary arten, disease. Atherosclerosis, 2000, 150: 381-387.
  • 4Schwertner HA. Association of smoking and low serum bilirubin antioxidant concentrations. Atherosclerosis, 1998, 136:383-387.
  • 5Olinescu R, Kummerow FA, Greabu M, et al. The levels of bilirubin may be related to an inflammatory condition in patients with coronary heart disease. Rom J Intern Med,1999,37 : 239-249.
  • 6李熹娟 白惠芙.胆红素与冠心病研究进展[J].心血管病学进展,2007,26:246-250.
  • 7Shimomura H, Ogawa H, Takazoe K, et al. Comparison of urinary biopyrrinlevels in acute myocardial infarction (after reperfusion therapy)versus stable angina pectoris and their usefulness in predicting subsequent cardiac events. Am J Cardiol,2002,90 : 108-111.
  • 8Lin JP, O'Donnell CJ, Schwaiger JP. Association between the UGTIAI * 28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study. Circulation, 2006,114:1476-1481.

同被引文献21

引证文献3

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部