摘要
目的通过对卵巢早衰（premature orian tfailure,POF）患者临床特征、病因及治疗现状的分析,更好地制定POF治疗方案。方法分析我院2005年1月～2008年1月确诊的POF患者50例临床特征,并对同期50例正常对照患者临床数据及POF组治疗前后数据变化进行比较。结果POF组初潮年龄与对照组无差别,POF组体重指数（BMI）大于对照组（P〈0.05）,POF组子宫及卵巢体积明显小于对照组（P〈0.01）。11例POF患者有家族史,占22%。43例（86%）患者阴道超声可探及至少一侧卵巢,11例（22%）患者有卵泡样回声,1例予人工周期及促排卵治疗后成功妊娠。POF组治疗有效者血清服药后较服药前卵泡刺激素（FSH）显著下降（P〈0.01）,黄体生成素（LH）与无效组都显示下降,雌二醇（E2）均上升。人流次数POF组大于对照组（P〈0.05）。POF组中16%（8/50）患者从未接受诊治,14%（7/50）患者间断未正规治疗。结论特发性POF是POF的最常见类型,占81%,良好的生活习惯,有效避孕,医源性保护等有助于预防POF发生。对POF患者改善临床症状,预防并发症应进行及时、长期、个体化的激素替代治疗（homone replacement treatment,HRT）。
Objective Through the analysis of clinical characteristics, etiology,treatment status in patients with premature ovarian failure（ POF）, the treatment programmes could be made better. Methods 50 cases＇ clinical characteristics confirmed to be POF were analyzed. Clinical data in 50 normal control patients with the same period and data changes before and after treatment in POF group were compared. Results Menarcheal age made no difference in both groups. BMI in POF group was more than control group（ P 〈 0.05 ）. Uterine and ovarian volume in POF group was smaller than the control group（ P 〈 0.01 ）. 11 patients with POF had a family history （22 % ） . One ovary at least with transvaginal ultrasound could be detected in 43 patients, follicular echo existed in 11 patients and 1 cases succeeded in pregnancy with the treatment of artificial cycle and stimulating ovulation. Follicle stimulating hormone （ FSH ） was significantly decreased （ P 〈 0. 01 ） after taking medicine in the patients＇ serum with effective treatment in POF group, luteinizing hormone （LH）declined and estradiol （ E2 ） increased in effective and ineffective groups. The number of abortions in POF group was more than that of the control group （ P 〈 0. 05 ）. 16 % of patients had not received any teatment, 14 % of patients （ 7/50 ） got intermittent informal treatment. Conclusion Idiopathic POF was the most common type, accounting for 81%. Good lifestyle, effective contraception, iatrogenic protection contributed to the prevention of POF. HRT used to improve clinical symptoms, prevent complications should be timely, long-term and individualized.
出处
《四川医学》
CAS
2008年第6期743-746,共4页
Sichuan Medical Journal
关键词
卵巢早衰
阴道超声
性激素测定
激素替代治疗
premature ovarian failure
transvaginal ultrasound
sex hormones
hormone replacement treatment
