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SOCS和IFN对JAK／STAT活化的影响和意义 被引量：5

The influence and meaning of SOCS and IFN to the activation of JAK/STAT
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摘要 信号抑制因子（SOCS）是在细胞因子诱导下依赖JAK／STAT通路的信号传导而产生的，继而抑制细胞因子的信号传导，因此SOCS蛋白质被认为可以形成局部经典负反馈回路。IFN是由辅助性T细胞I类亚群和自然杀伤细胞等分泌的一种细胞因子，具有多种免疫调节功能。在炎症反应中IFN首先激活JAK，然后再活化与之相结合的STAT1和STAT3，从而引起iNOS诱生型一氧化氮表达增强而诱发炎症反应，而IFN在诱导细胞的抗病毒和抗生长反应中也起关键作用。IFN可正向调节SOCS的表达，但是SOCS的过度表达又可以抑制IFN受体的磷酸化及STAT1、STAT3的活化。 Suppressors of eytokine signaling （SOCS） can be generated by the stimulation of eytokines through the signal activation of JAK/STAT pathway, and can later restrain the signal transduction of cytokines. Therefore SOCS is regarded as partial classic negative feedback loop. Interferon （IFN） are cytokines secreted by helper T cell and natural killer cells, which play roles in immune regulation. During inflammato- ry reaction, IFN activates JAK firstly and then activates STAT1 and STAT3 which combine to JAK. The phosphorylated STAT strengthens the expression of iNOS and induces inflammatory reaction. IFN plays an important role in antivirus and anti - growth responses. IFN can induce the expression of SOCS, but over - expression of SOCS will restrain the phosphorylation of IFN receptor and STAT1 or STAT3. Here we summarize the influence of SOCS on the activation of JAK/STAT to the signal transduction of IFN.
作者 樊娟 邹典定(审校) 赵东赤(审校)
机构地区 武汉大学中南医院儿科
出处 《国际免疫学杂志》 CAS 2008年第4期311-313,共3页 International Journal of Immunology
关键词 SOCS IFN JAK/STAT信号传导通路 Suppressors of cytokine signaling Interferon Janus Kinase/signal transducers and activators of transcription
分类号 R285.5 [医药卫生—中药学]
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参考文献21

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共引文献32

同被引文献81

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引证文献5

二级引证文献42

国际免疫学杂志
2008年 第4期

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