摘要
在抗体依赖细胞介导的细胞毒性作用（ADCC）参与的体液免疫中，免疫球蛋白（IgG）扮演了很重要的角色。IgG通过其Fc段与效应细胞表面的Fc受体结合，发挥多种免疫学效应。淋巴细胞表面FcγRⅢ（CD16）属于（Ig）超家族成员，是人白细胞表面上与抗体结合的主要受体之一，由于转录和剪接的不同，CD16存在FcγRⅢA和FcγRⅢB两种异型。每种又由于基因的多态性而分为不同的亚型。CD16的基因多态性影响其与IgG亚型的结合能力，从而影响体液免疫，产生不同效应的免疫反应。CD16基因多态性与免疫相关性疾病的发生发展关系密切。
IgG plays an important role in the humoral immune mediated by antibody - dependent cellular cytotoxicity（ADCC）. It combines specific receptors on effector cells to mediate different immune responses. FcγRⅢ （CD16）, which is on the surface of human leukocytes, which bind to antibodies. It has two gene polymorphisms： FcγRⅢA and FcγRⅢB. Genetic polymorphisms of each one affects their binding ability to the subtype of IgG, thus influences humoral immune by inducing different immune responses. CD16 gene polymorphisms has a close relationship with the occurrence and development of immune related diseases. This paper is to summarize this relationship.
出处
《国际免疫学杂志》
CAS
2008年第4期303-307,共5页
International Journal of Immunology
