摘要
目的探讨多形性黄色瘤型星形细胞瘤的影像表现与临床病理特点。资料与方法回顾分析21例脑多形性黄色瘤型星形细胞瘤的CT、MR表现和临床病理特点。结果病变好发于脑实质表浅部位,单发,多位于颞叶;15例病变以囊性为主,其中10例为大囊小结节,5例大囊大结节;6例病变以实性为主。组织病理学检查,肿瘤细胞具有明显多形性,瘤细胞间见大量网状纤维及淋巴细胞浸润;出血、钙化少见。免疫组织化学示所有病例胶原纤维酸性蛋白表达阳性。临床上该病好发于儿童及青少年,多有癫痫发作。结论多形性黄色瘤型星形细胞瘤的影像学表现具有一定特征,病变表浅且单发,多呈囊性改变并伴有壁结节,结合应用影像诊断新技术(DWI、MRS及PET/CT)有助于提高诊断能力。
Objective The purpose of this study was to analyze the imaging features and pathological findings of pleomorphic xanthoastrocytomas. Materials and Methods Imaging, clinical and pathological features of pleomorphic xanthoastrocytomas in 21 cases were analyzed retrospectively. Results On CT and MRI, most pleomorphic xanthoastrocytomas were located in the superficial cerebral hemisphere, mostly in the temporal lobe. Solitary lesion was most common. 15 cases predominantly appeared as cystic lesion with small mural nodule （n = 10） or large mural nodule （n = 5 ） ;6 cases showed as solid mass with small cystic or necrotic changes. Histopathologically, tumor cells were characterized by plcomorphism ,which were embedded in a dense fibrillary matrix and lymphocyte. Hemorrhage and calcification were rare. Immunohistochemically, the neoplastic cells were strongly positive for glial fibrillary acidic protein. It generally occurred in children and youth with seizures. Conclusion Superficial location, solitary and cystic lesion with enhanced mural nodule were typical imaging features of pleomorphic xanthoastrocytom. Combined With advanced imaging technology, such as DWI, MRS, and PET/ CT may contribute to improve the diagnosis.
出处
《临床放射学杂志》
CSCD
北大核心
2008年第6期726-730,共5页
Journal of Clinical Radiology
基金
973基金资助项目(编号:2006CB705707)
