摘要
目的探讨早期应用纳络酮治疗颅脑损伤并脑疝开颅术后患者的临床效果。方法108例颅脑损伤并脑疝开颅术后患者采用随机数字表法分为治疗组及对照组．对照组按照常规治疗方法进行治疗，治疗组在常规治疗的基础上早期应用纳络酮：观察两组患者早期呼吸和心跳异常情况、意识恢复情况及远期疗效。结果治疗组患者伤后1周内呼吸和心跳异常减少．与对照组比较差异有统计学意义（P〈0．01）；伤后14d及伤后1个月患者意识醒转率显著高于对照组（P〈0．05）；伤后3个月治疗组预后显著优于对照组（P〈0．05）。结论早期应用纳络酮可以改善颅脑损伤并脑疝开颅术后患者呼吸和循环功能，缩短昏迷时间．降低死残率，促进患者神经功能恢复。
Objective To explore the effect of naloxone （NLX） on patients with severe head injury and herniation of brain after the craniotomy. Methods A total of 108 patients with severe brain injury and herniation of brain were divided into 2 groups： NLX group was treated with NLX and general therapy and control group was treated only by general therapy after the craniotomy. The abnormal respiration and heartbeat, recovery of consciousness at the early period and the prognosis at the later period were observed and all the data were analyzed statistically. Results The abnormal respiration and heartbeat of patients were significantly less in NLX group than in control group in the first 7 d after injury （P〈0.01）. More patients revived in NLX group than in control group 14 d and 1 month after injury （P〈0.05）. The prognosis of NLX group was significantly better than that of control group 3 months after injury （P〈0.05）. Conclusion The early administration of NLX in patients with severe head injury and herniation of brain after the craniotomy can ameliorate the function of respiration and circulation, shorten the coma duration, reduce the incidence of disability and death, and improve the nerve function.
出处
《中华神经医学杂志》
CAS
CSCD
2008年第6期634-636,共3页
Chinese Journal of Neuromedicine
关键词
纳络酮
颅脑损伤
脑疝
Naloxone
Craniacerebral trauma
Cerebral hernia
