摘要
肿瘤生长、浸润和转移都依赖于肿瘤血管生成,而肿瘤血管生成又受多种因子影响.血管内皮生长因子(VEGF)是最重要的血管生成因子,可特异性作用于血管内皮细胞生长因子受体(VEGFR),通过促进内皮细胞增殖,增加血管通透性,而诱导肿瘤血管生成.因而以VEGF及VEGFR为靶点抗肿瘤血管生成已越来越成为人们研究的热点.对以VEGF及VEGFR为靶点抗肿瘤血管生成的治疗进展作一综述.
Tumor growth, invasion and metastases all depend on tumor angiogenesis, tumor angiogenesis are influenced by many factors. Vascular endothelial growth factor （VEGF） is a very important factor in the process of angiogenesis. It can bind with vascular endothelial growth factor receptor （VEGFR）, and induce tumor angiogenesis by promoting generation of endothelial cell and augmenting vasopermeability. So the study of targeting VEGF and VEGFR has become hot. This article reviewed advance in of tumor of targeting VEGF and VEGFR anti-angiogenesis.
出处
《昆明医学院学报》
2008年第B06期70-73,共4页
Journal of Kunming Medical College
基金
云南省自然科学基金资助项目(2005C0073M)
昆明医学院创新群体研究基金资助项目(KMC2005DG01)
