摘要
目的检测RXRα基因蛋白在胃癌、浅表性胃炎、正常胃黏膜中的表达,探讨其与胃癌发生发展的关系,并结合临床、病理资料分析其临床意义。方法用免疫组织化学ABC法检测RXRα蛋白在胃癌、浅表性胃炎、正常胃黏膜中的表达情况。结果RXRα蛋白主要定位于上皮细胞的胞核,少数胞质有着色,呈棕黄色或黄色颗粒状,在胃癌、浅表性胃炎、正常胃黏膜中,RXRα蛋白阳性表达率分别为25.0%、81.1%、96.1%;与正常黏膜组和浅表性胃炎比较,胃癌组RXRα表达率下降,差异有显著性(P<0.05);RXRα蛋白表达与肿瘤分化程度无相关性(P>0.05),而与肿瘤淋巴结转移和临床病理分期密切相关(P<0.05)。结论胃癌组织中RXRα蛋白表达显著低于正常黏膜和浅表性胃炎组,提示RXRα蛋白表达下降对胃癌预后具有重要意义。
Objective To detect the expression of RXRα gene protein in gastric cancer, superficial gastritis, normal gastric mucosa, in order to explore the relationship between the development of gastric cancer, combined with clinical and pathological analysis of its clinical significance. Methods Using immunohistoehemieal detection RXRα protein in gastric cancer, superficial gastritis, gastric mueosa in the normal expression. Resolts RXRα protein mainly located in the nucleus of cells, there are a small number of cytoplasmic staining, a brown or yellow granular, in gastric cancer, superficial gastritis, normal gastric mueosa, RXRα protein expression rates were 25.0% , 81. 1%, 96. 1% ; group and the normal mueosa and superficial gastritis, gastric cancer group RXRα expression rate has dropped, there were significant differences （ P 〈 0.05 ） ; RXRα expression and the degree of tumor differentiation no correlation （P 〉 0.05 ）. The lymph node metastasis and tumor pathology and clinical phases closely related （P 〈 0.05）. Conclusion Gastric cancer tissues RXR α protein expression was significantly lower than mueosa and superficial gastritis group, suggesting that RXRα decreased expression of gastric cancer prognosis is of great significance.
出处
《医学研究杂志》
2008年第6期41-43,F0003,共4页
Journal of Medical Research
基金
唐山市科学技术研究与发展指导计划项目(07134604C)
关键词
RXRα
胃癌
浅表性胃炎
正常黏膜
RXRα
Gastric cancer
Superficial gastritis
Normal mucosa
