摘要
目的评价门诊危险因素暴露者的卒中风险及脑安胶囊预防卒中的效果。方法在2005—2007年秦皇岛军工医院门诊患者中，选择具有高血压、心脏病、糖尿病、脂代谢紊乱、肥胖和中风家族史等卒中危险因素暴露者（1500例），采用有多普勒探头和压力传感探头的脑血管血流动力学监测仪进行颈动脉脑血管血流动力学检测和危险因素的调查，按知情同意的原则，在血流动力学积分值（CVHI）〈75分者中选择278例作为干预对象，并随机分为2组（脑安胶囊组132例，对照组146例），脑安胶囊组在健康教育、指导危险因素治疗等一般干预措施的基础上，口服脑安胶囊（CVHI积分值〈50分者，脑安胶囊2粒／次，2次／d，其中积分值〈25分者，睡前再加服1粒；积分值50—74分的个体，脑安胶囊1粒／次，2次／d。），对照组仅给予一般干预措施，卒中发生率每6个月随访1次，共随访2年。结果1500例门诊患者中，高血压、心脏病、糖尿病、卒中家族史和肥胖的暴露率分别为36．7％（550／1500）、22．4％（336／1500）、19．5％（292／1500）、9．9％（148／1500）和27．6％（414／1500），血流动力学积分值〈75分者占50．7％，脑安胶囊干预组和对照组的2年卒中累积发生率分别为2．3％（3／132）和7．5％（11／146），P=0．0767，脑安胶囊组干预后，CVHI≥50分者由55．6％上升到88．2％，对照组由64．38％上升至84．93％（P〈0．01）。结论医院门诊常见危险因素暴露者中，卒中风险明显升高；脑安胶囊能改善脑血管血流动力学，降低卒中的发生率。
Objective To estimate the risk of stroke in risk factors exposed outpatient and to evaluate the efficacy of Naoan Capsule for prevention of stroke. Methods Among outpatients in Qinhuangdao Jungong Hospital from 2005 to 2007, 1500 outpatients with risk factors of stroke （such as hypertension, heart disease, diabetes, dyslipidemia, obesity and family history of stroke） were accepted cerebrovascular hemodynamic detection and risk factor investigation. The participants whose cerebrovascular hemodynamic score below 75 points and willing to be a volunteer of intervention trial were divided into experimental group （132 cases） and control group （146 cases）. The volunteers of experimental group was received general healthcare education and Chinese medicine ＂Naoan capsules＂ intervention （2 pills bid in persons with CVHI score below 50 points, add 1 pill before sleep in persons with CVHI score below 25 points and 1 pill bid in persons with CVHI score 50 - 74 points ）. The control group was accepted general interventional measures. All the volunteers were followed up once every 6 months and lasted for 2 years. Results The exposure rate of hypertension, heart disease, diabetes, family history of stroke and obesity in 1500 outpatients were 36.7%, 22.4%, 19.5%, 9.9% and 27.6%, respectively. The hemodynamic score below 75 points were 50.7%. 2 years accumulative incidence of stroke in Naoan capsules intervention group and controls group were 2.3% （3/132） and 7.5% （11/146） , P = 0. 0767. After Naoan intervention, the proportion of CVHI score≥50 points increased from 55.6% to 88.2 and increased from 64.4% to 84.9% in the control group （ P 〈 0.01 ）. Conclusions Risk of stroke in risk factor exposed outpatients increases obviously. Naoan Capsules may improve cerebrovascular hemodynamics and reduce the incidence of stroke.
出处
《中国脑血管病杂志》
CAS
2008年第6期263-266,共4页
Chinese Journal of Cerebrovascular Diseases
关键词
脑血管意外
血液动力学过程
干预性研究
Cerebrovascular accident
Hemodynamic processes
Intervention studies
