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抑郁症病因学和治疗学的研究进展 被引量：3

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摘要 抑郁症（major depressive disorder，MDD）以情感低落或兴趣减退为主要临床特征，并伴有认知、行为、生物学紊乱和躯体症状。抑郁症的终身患病率为15％～17％，年患病率6％～7％，全球患者高达3．4亿。抑郁症患者中约60％伴有自杀观念或自杀行为，约15％～25％的抑郁症患者自杀死亡。目前，抑郁症已成为世界第4位致残性疾病，且预计2020年将跃居到第2位。抑郁症已经成为全球主要的公共卫生问题，但其病因尚不清楚，有关抑郁症的药物治疗也受到公众的质疑。现就抑郁症的病因学和治疗学的研究进展作一综述。
作者 史艳艳 袁勇贵 李晶晶 张志珺
机构地区 南京医科大学附属脑科医院精神科 东南大学附属中大医院神经内科
出处 《中国行为医学科学》 CSCD 2008年第6期575-576,共2页 Chinese Journal of Behavioral Medical Science
关键词 抑郁症 病因学 治疗学 公共卫生问题 自杀行为 临床特征 躯体症状 自杀观念
分类号 R749.4 [医药卫生—神经病学与精神病学] R45 [医药卫生—治疗学]
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参考文献21

  • 1Fava M,Kendler KS. Major depressive disorder. Neuron,2000,28:335-341.
  • 2潘玉芹,林文娟.海马5-羟色胺系统与抑郁症[J].中国行为医学科学,2006,15(4):379-380. 被引量：29
  • 3Chen TJ,Yu YW,Hong CJ,et al. Association analysis for the C-1019G promoter variant of the 5-HT1A receptor gene with auditory evoked potentials in major depression. Neuropsychobiology ,2004,50:292-295.
  • 4Den Boer JA. Looking beyond the monoamine hypothesis. European Neurological Disease ,2006,32:2-3.
  • 5Svennirlgsson P,Chergui K,Rachleff I,et al. Aherations in 5-HT1B receptor function by p11 in depression-like states. Science,2006,311:77-80.
  • 6Tsai SJ. The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants. Medical Hypotheses, 2007, 68 : 180-183.
  • 7Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neuregenesis for the behavioral effects of antidepressants. Science, 2003, 301:805-809.
  • 8Gage FH. Mammalian neural stem ceils. Science, 2000,28: 1433- 1438.
  • 9Campbell S, Macqueen G. The role of the hippocanrpus in the pathophysiology of major depression. J Psychiatry Neurosci ,2004,29:417-426.
  • 10Chen SJ, Kao CL, Chang YL,et al. Antidepressant administration modulates neural stem cell survival and serotoninergic differentiation through bc1-2. Curr Neurovasc Res ,2007,4 : 19-29.

二级参考文献21

  • 1马静.经络氧辅助治疗抑郁症的疗效观察[J].山东精神医学,2004,17(3):161-163. 被引量：5
  • 2Philippe F.Neuroplasticity:from MRI to depressive symptoms.European Neuropsychopharmacology,2004,14:503-510.
  • 3Barry L.Adult brain neurogenesis and depression.Brain,Behavior and Immunity,2002,l6:602-609.
  • 4Mitsuhiko Y,Misa Y,Teruhiko H,et al.Antidepressant-elicited changes in gene expression:Remodeling of neuronal circuits as a new hypothesis for drug efficacy.Progress in Neuro-Psychopharmacology and Biological Psychiatry,2005,29:999-1009.
  • 5Claus N,Kristin C.Selective modulation of Ca^2+ influx pathways by 5-HT regulates synaptic long-term plasticity in the hippocampus.Brain Research.2005,1037:187-193.
  • 6Hjorth S,Bengtsson HJ,Kullberg A,et al.Serotonin autoreceptor function and antidepressant drug action.Journal of Psychopharmacology,2000,14:177-185
  • 7Shuji M,Hiroki I,Yoshihiro M,et al.Chronic stress,as well as acute stress,reduces BDNF mRNA expression in the rat hippocampus but less robustly.Neuroscience Research,2005,15:1-11.
  • 8Sargent PA,Kjaer KH,Bend CJ,et al.Brain serotonergic neurotransmission in depression,hippocampusal pathophysiology:mirrior global brain alteration.Bio Psychiatry,2000,48:801-812.
  • 9Duman RS,Heninger GR,Nestler EJ,etal.A molecular and cellular theory of depression.Arch Gen Psychiatry,1997,54:497-608.
  • 10Menz J,Kadia TM,Somayazula PK,et al.Differential coupling of serotonin 5-HT1A and 5-HT1B receptor to activation of ERK2 andinhibition of adenylyl cyclase in tran-sfected CHO cells.J Neurochemistry,1999,73:162-168.

共引文献32

同被引文献40

  • 1周浩,龙立荣.共同方法偏差的统计检验与控制方法[J].心理科学进展,2004,12(6):942-950. 被引量：4332
  • 2朱熊兆,罗伏生,姚树桥,Randy P.Auerbach,JohnR.Z.Abela.认知情绪调节问卷中文版(CERQ-C)的信效度研究[J].中国临床心理学杂志,2007,15(2):121-124. 被引量：300
  • 3Honore E. The neuronal background K2P channels:focus on TREK1 [ J ]. Nat Rev Neurosci, 2007,8 (4) : 251-261.
  • 4Dedman A, Sharif-Naeini R, Folgering JH, et al. The mechano-gated K (2P) channel TREK- 1 [ J ]. Eur Biophys J,2009,38 (3) : 293-303.
  • 5Fink M, Duprat F, Lesage F, et al. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ chan- nel [ J ]. EMBO J, 1996. 15 (24) : 6854-6862.
  • 6Lesage F, Lazdunski M. Molecular and functional properties of two- pore-domain potassium channels [ J ]. Am J Physiol Renal Physiol, 2000,279(5) :F793-801.
  • 7Hervieu GJ, Cluderay JE, Gray CW, et al. Distribution and expression of TREK-I, a two-pore-domain potassium channel, in the adult rat CNS[J]. Neuroscience,2001,103(4) :899-919.
  • 8Talley EM, Solorzano G, Lei Q, et al. CNS distribution of members of the two-pore-domain (KCNK) potassium channel family [ J ]. J Neu- rosci, 2001,21 (19) : 7491-7505.
  • 9Blondean N, Petrault O, Manta S, et al. Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel[ J] .Circ Res, 2007,101 (2) : 176-184.
  • 10La JH, Schwartz ES, Gebhart GF. Differences in the expression of tran-sient receptor potential channel V1, transient receptor potential chan- nel A1 and mechanosensitive two pore-domain K channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon [ J ]. Neuroscience, 2011,186 : 179-187.

引证文献3

二级引证文献3

中国行为医学科学
2008年 第6期

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