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NF-κB与急性胰腺炎

NF-κB and Acute Pancreatitis
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摘要 核因子κB(NF-κB)是一种核蛋白,能与体内多种细胞基因启动子部位相结合,在机体的免疫功能、炎性反应和凋亡调控等方面发挥多向性调节作用,其在多种疾病中的作用已日益受到人们的重视。近年来的研究证实,NF-κB与急性胰腺炎关系密切,成为一个新的研究热点。 NF-KB is a kind of neucleoprotein with pleiotropic accommodation roles, which can combine with many promoters in vivo and plays important roles in immune function,inflammatory reaction and apoptosis-regulatory. Many scholars have played much attention in the roles of NF-KB in many diseases in the past few years. NF-KB has been demonstrated to be closely related to acute pancreatitis,and has been a new research warm spots.
作者 夏淑晶 许春芳
机构地区 苏州大学附属第一医院消化内科
出处 《医学综述》 2008年第12期1770-1772,共3页 Medical Recapitulate
关键词 急性胰腺炎 核因子ΚB 调控 Acute pancreatitis Nuclear factor kappaB Ceontrol
分类号 R576 [医药卫生—消化系统]
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参考文献24

  • 1Roland MS, Guido A. NF-κB/Re 1/IκB:implications in gastrointestinal disease [ J ]. Gastroenterology ,2000,118 (6) : 1208-1228 .
  • 2Chen X,Ji B, Han B, et al. NF-κB activation in pancreas induces pancreatic and systemic inflammatory response [ J ]. Gastroenterology,2002,122(2) ;448-457 .
  • 3Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhance sequences cell [ J ]. Cell, 1986,46 ( 5 ) : 705 -716.
  • 4Thranos D, Maniatis T. NF-κappaB:a lesson in family values [ J]. Cell, 1995,80(4 ) :529-532.
  • 5Parry GC, Mackman N. A set of inducible genes expressed by activated human monocytic and endothelital cells contain κappaB-like sites that specifically bind c-Rel-p65 heterodimers [ J ]. J Biol Chem, 1994,269 (33) :20823-20825.
  • 6Denham W, Norman J. The potential role of therapeutic cytokine manipulation in acute pancreatitis [ J ]. Surg Clin North Am, 1999, 79(4) :767-781.
  • 7Wang CY,Mayo MW,Komeluk RG,et al. NF-κappaB antiapoptosis:induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 tosuppress caspase8 activation [ J ]. Science, 1998,281 ( 5383 ) : 1680-1683.
  • 8Blackwell TS, Chrristmal JW. The role of nuclear factor-κappaB in cytokine gene regulation[ J ]. Am J Respir Cell Mol Biol, 1997,17 (1):3-9.
  • 9Steinle AU, Weidenbach H, Wagner M, et al. NF-κB/Rel activatin in cemlein pancreatitis [ J ]. Gastroenterology, 1999, 116 (2) : 420-430.
  • 10Gukovsky I, Gukovskaya AS, Blinman TA, et al. Early NF-κappaB activation is associated with hormone-induced pancreatitis [ J ]. Am J Physiol,1998,275(6) : 1402-1414.

二级参考文献42

  • 1[1]Elliott PJ,Zollner TM,Boehncke WH.Proteasome inhibition:a new anti-inflammatory strategy.J Mol Med 2003; 81:235-245
  • 2[2]Lawrence T,Gilroy DW,Colville-Nash PR,Willoughby DA.Possible new role for NF-kappaB in the resolution of inflammation.Nat Med 2001; 7:1291-1297
  • 3[3]Weber CK,Adler G.From acinar cell damage to systemic inflammatory response:current concepts in pancreatitis.Pancreatology 2001; 1:356-362
  • 4[4]Algul H,Tando Y,Schneider G,Weidenbach H,Adler G,Schmid RM.Acute experimental pancreatitis and NF-kappaB/Rel activation.Pancreatology 2002; 2:503-509
  • 5[5]Bhatia M,Wong FL,Cao Y,Lau HY,Huang J,Puneet P,Chevali L.Pathophysiology of acute pancreatitis.Pancreatology 2005; 5:132-144
  • 6[6]Weber CK,Adler G.Acute pancreatitis.Curr Opin Gastroenterol 2003; 19:447-450
  • 7[7]Adler G.Has the biology and treatment of pancreatic diseases evolved? Best Pract Res Clin Gastroenterol 2004; 18 Suppl:83-90
  • 8[8]Bhatia M,Neoptolemos JP,Slavin J.Inflammatory mediators as therapeutic targets in acute pancreatitis.Curr Opin Investig Drugs 2001; 2:496-501
  • 9[9]Bhatia M.Inflammatory response on the pancreatic acinar cell injury.Scand J Surg 2005; 94:97-102
  • 10[10]Letoha T,Somlai C,Takacs T,Szabolcs A,Rakonczay Z Jr,Jarmay K,Szalontai T,Varga I,Kaszaki J,Boros I,Duda E,Hackler L,Kurucz I,Penke B.The proteasome inhibitor MG132 protects against acute pancreatitis.Free Radic Biol Med 2005; 39:1142-1151

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医学综述
2008年 第12期

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