摘要
为探讨肾移植术后肿瘤坏死因子（ＴＮＦα）在移植肾排斥反应（ＡＲ）诊断与鉴别诊断中的意义，采用液相竞争放射免疫法动态监测６０例肾移植患者术后血清、尿液及肾组织液中ＴＮＦα水平的变化。结果：ＡＲ组ＴＮＦα水平在血清、尿液及肾组织液中均显著升高，以肾组织液中升高最明显，比临床症状的出现早１～２天；ＣｓＡ肾中毒组ＴＮＦα水平轻度升高，但无统计学意义；急性肾小管环死（ＡＴＮ）组肾组织液及尿液中ＴＮＦα水平均显著升高；急性感染组仅血清中ＴＮＦα水平显著升高。结论：动态监测血清、尿液和肾组织液中ＴＮＦα水平能较好地早期诊断和鉴别诊断ＡＲ、急性感染、ＣｓＡ肾中毒和ＡＴＮ。
Serum, urine and kidney aspirate levels of tumour necrosis factor alpha(TNFα)were sequentially measured with radioimmunoassay for 60 renal allograft recipients. With the occurrence of acute rejcetion of the graft, TNFα levels became evidently higher in serum, urine and kidney aspirate and could be detected 1～2 days before the elevation of serum creatinine, the kidney aspirate level being the highest. During acute tubular necrosis, both urine and kidney aspirate TNFα levels were elevated while only the serum level elevated during acute infection. It was suggested that sequential evaluation of serum and urine TNFα levels were of value in the early detection of acute rejection and also of value in the treatment and prognosis. TNFα assays were of value in the differential diagnosis of acute rejection, acute infection, CsA nephrotoxicity and acute tubular necrosis.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1997年第12期716-719,共4页
Chinese Journal of Urology
