摘要
通过建立臂丛节前损伤的模型,观察撕脱的背根神经节通过相连的外周神经是否对相应的骨骼肌有延缓萎缩的作用,以期寻找防止肌萎缩的方法。方法:选用雄性成年SD大鼠60只,随机分成2组。实验组:制成C_5C_6根性撕脱的模型,使拖出椎孔的背根神经节仅通过肌皮神经与完全失神经支配的肱二头肌有联系。对照组:于椎孔外切断C_5C_6神经根,并造成肱二头肌完全失神经支配。于术后1、2、3、4和5个月各时间段,分别测定肱二头肌纤颤电位波幅、肌张力、肌湿重、肌纤维截面积并观察背根神经节中感觉神经元的变化。结果:术后1～5个月背根神经节中均见到存活的感觉神经元;纤颤电位波幅实验组大于对照组;实验组肌张力于术后1、2个月时明显优于对照组;术后1、2、3个月,实验组的肌湿重、肌纤维截面积明显高于对照组。结论:在节前损伤1～3个月内,背根神经节中感觉神经元有延缓失神经支配骨骼肌萎缩的作用。
Objective:An experimental model of preganglionic avulsion of brachial plexus was set up to investigate
whether the dorsal root ganglion (DRG) of the rat could survive and exert beneficial influence to delay the degeneration of denervated muscles. Methods: C5C6 nerve roots were avulsed preganglionically in the experimental group. DRG of C5 C6 were connected to the completely denervated biceps brachialis via musculocutaneous nerve. In the control rats, C5C6 nerve roots were cut postganglionically, and biceps brachialis denervated. Fibrillation potential amplitude, twitch tension & tetanic tension, wet weight and cross sectional area of muscle fibers of biceps brachialis were tested in 1, 2, 3, 4, and 5 months of postoperative intervals respectively. Changes of the sensory neurons in DRG were also observed. Results: Sensory neurons were found to survive in DRG throughout the experiment. Fibrillation potential amplitude of the experimental group was higher than that of controls. In 1 ~ 3 postoperative months, the twitch and tetanic tensions, wet weight and muscle fiber cross sectional area of the denervated muscles were significantly higher in the experimental rats than in the control rats. Conclusion: Sensory neurons of DRG had the effect of delaying atrophy of denervated skeletal muscles within 3 months after preganglionic avulsion.
出处
《中华手外科杂志》
CSCD
1997年第4期231-234,共4页
Chinese Journal of Hand Surgery
基金
美国中华医学基金
国家自然科学基金
卫生部科研基金资助项目
关键词
周围神经
肌萎缩
脊神经节
神经元
Peripheral nerve Muscle atrophy Ganglia, spinal Neurons, afferent
