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蛋白酪氨酸磷酸酶抑制剂研究进展 被引量：1

Recent Progress in Research on Protein Tyrosine Phosphatases Inhibitors
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摘要 蛋白酪氨酸磷酸酶催化蛋白质酪氨酸去磷酸化反应,在调控细胞生命活动中起着重要作用。蛋白酪氨酸磷酸酶的生理功能与诸多人类疾病有密切关系,例如癌症、神经系统疾病、糖尿病和肥胖等。蛋白酪氨酸磷酸酶已经成为治疗上述疾病的靶标。文章综述了近年来蛋白酪氨酸磷酸酶抑制剂的研究进展。 The protein tyrosine phosphatases （PIPs） are a family of closely related enzymes that dephosphorylate phosphotyrosine residues in their protein substrates and play the key regulatory role during cell cycle. Malfunctions in PTP activity are linked to various diseases, ranging from cancer to neurological disorders and diabetes. PTPs have been the promising targets for therapeutic intervention in recent years and here PTPs inhibitors were reviewed.
作者 班树荣
机构地区 山西医科大学
出处 《忻州师范学院学报》 2008年第2期3-8,共6页 Journal of Xinzhou Teachers University
基金 山西医科大学博士启动基金资助
关键词 蛋白酪氨酸磷酸酶 抑制剂 综述 protein tyrosine phosphatases inhibitors review
分类号 R914 [医药卫生—药物化学]
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参考文献34

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二级参考文献16

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忻州师范学院学报
2008年 第2期

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