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染色体异常在非霍奇金淋巴瘤临床应用中的价值

Evaluation of Chromosomal Abnormalities in Non-Hodgkin's Lymphomas——Review
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摘要 非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)是一组来源不同、生物学特征各异的异质性疾病。大量研究表明,非霍奇金淋巴瘤患者常伴有特异性的染色体异常。随着分子生物学和细胞遗传学的发展,有关NHL染色体核型异常在NHL诊断、治疗乃至预后判断中的价值的研究取得了重大的进展。本文就NHL的常见的几种染色体异常和染色体异常的检测在临床应用中的价值做一综述,并重点讨论非霍奇金淋巴瘤的分子异常,它不仅是其分子特点,而且是预测其预后和治疗反应的指征。 Non-Hodgkin＇s lymphoma （NHL） is a heterogenous disease from various resources and biological characters. Many researches indicated molecular abnormal characteristics in patients with NHL. Currently, NHLs are diagnosed according to the World Health Organisation classification. With the advances in molecular biology and cytogenetics, the cell as a morphological and functional unit has become essential in the diagnosis, therapy and prognosis of lymphoma. The signification of abnormal karyotypes has been more and more focused on, and great progression has been made. Accepting the pitfalls of conventional cytomorphology and immunophenotype, this review emphasizes molecular abnormelities in non -Hodgkin＇s lymphomas, which are not only a molecular characterization, but also an indicator to predict prognosis and response to treatment.
作者 张蕾 赵小英
机构地区 浙江大学医学院附属第二医院血液科
出处 《中国实验血液学杂志》 CAS CSCD 2008年第3期717-720,共4页 Journal of Experimental Hematology
关键词 染色体核型检测 非霍奇金淋巴瘤 遗传学 chromosomal karyotype detection non-Hodgking lymphoma cytogenetics
分类号 R733 [医药卫生—肿瘤] R596.1 [医药卫生—内科学]
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参考文献24

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中国实验血液学杂志
2008年 第3期

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