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血清TNF-α、血管紧张素Ⅱ在CHF患者血红蛋白水平变化中的作用及其与心室重构关系的研究 被引量：3

Role of INF-α,angiotensin Ⅱ in hemoglobin concentration changes and their correlation with ventricular remodeling in patients with congestive heart failure
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摘要 目的:研究血清肿瘤坏死因子α(TNF-α)、血管紧张素Ⅱ(AngⅡ)在慢性心力衰竭(CHF)患者血红蛋白水平变化中的作用,探讨肾素-血管紧张素系统、炎症细胞因子、血红蛋白水平变化与心室重构的关系。方法:对入选的121例CHF患者测定了血红蛋白、血清TNF-α和AngⅡ水平,超声心动图测量左室射血分数(LVEF),评价心功能;计算左心室质量指数(LVMI)和室壁应力(MWS);按血红蛋白水平将CHF分为贫血组和非贫血组,同时选择27例正常人作为对照组。结果:CHF患者Hb水平低于正常对照组,而血清TNF-α和AngⅡ水平以及MWS和LVMI高于对照组(P<0.01);随着心功能恶化,Hb水平逐渐降低,而血清TNF-α和AngⅡ水平以及MWS和LVMI逐渐升高;CHF贫血组患者血清TNF-α和AngⅡ水平以及MWS和LVMI明显高于非贫血组患者(P<0.01);随着Hb水平降低,CHF患者血清TNF-α和AngⅡ水平以及MWS和LVMI明显升高(P<0.01);CHF患者MWS和LVMI与Hb水平呈负相关,与TNF-α、AngⅡ水平呈正相关(P<0.01)。结论:CHF患者TNF-α和AngⅡ水平的升高参与了CHF贫血和心室重构发生发展的病理生理过程,而CHF患者贫血的出现使CHF心室重构加重。
作者 郗爱旗 褚以德 钟欣 尚玲 赵文蕊 李国峰 李英兰 廖宝霞
机构地区 青海省人民医院老年医学研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2008年第6期1234-1236,共3页 Chinese Journal of Pathophysiology
基金 青海省科技厅自然科学基金资助项目(No2006-N-149)
关键词 心力衰竭 充血性 血管紧张素II 肿瘤坏死因子 心室重构 Heart failure, congestive Angiotensin II Tumor necrosis factor Ventricular remodeling
分类号 R541.61 [医药卫生—心血管疾病]
  • 相关文献

参考文献7

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二级参考文献13

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共引文献18

同被引文献36

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中国病理生理杂志
2008年 第6期

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