摘要
目的：了解大剂量山莨菪碱及地塞米松对多脏器功能失常综合征兔微循环变化的影响。方法：将日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）术，造成腹腔感染致多器官功能障碍的动物模型，其中实验组和对照组各１１只，应用瑞典ＰＥＲＩＭＥＤ公司的新型４００１双通道激光多普勒血流仪动态测定应用大剂量山莨菪碱（３ｍｇ／ｋｇ）及地塞米松（１０ｍｇ／ｋｇ）时兔耳及大腿肌肉内微循环的变化。结果：对照组静注生理盐水后大腿肌肉内微循环的灌注量由（３２６．１５±８７．３２）ＰＵ增加到（６５６．７８±１０２．５０）ＰＵ，兔耳微循环的灌注量由（８．５０±１．８５）ＰＵ增加到（１１．４９±３．４２）ＰＵ。实验组静注大剂量山莨菪碱及地塞米松后大腿肌肉内微循环的灌注量由（２９０．５０±２０．１８）ＰＵ增加到（６９１．３９±１０２．０７）ＰＵ，兔耳微循环的灌注量由（５．３６±３．２６）ＰＵ增加到（１９．７８±１０．１０）ＰＵ。结论：静注大剂量山莨菪碱及地塞米松能明显改善兔在多器官功能障碍时微循环的灌注，对保护和维持重要脏器的功能十分有利。
Objective:To investigate the influence of high doses of anisodamine and dexamethasone treatment on microcirculation in rabbits with multiple organ dysfunction syndrome (MODS).Methods:A rabbit model of MODS was produced by cecum ligation and perforation,and 26 rabbits were randomly divided into MODS group ( n =15) and control group ( n =11).PERIMED 4001 Master Laser Doppler was used to determine the realtime of microvascular perfusion after treatment with high doses of anisodamine (3 mg/kg) and dexamethasone (10 mg/kg).Results:In the control group,the microvascular perfusion increased in leg muscle from (326 15±87 32) PU to (656 78±102 50) PU,and in ear from (8 50±1 85)PU to (11 49±3 42) PU after treatment.In MODS group,the microvascular perfusion increased in leg muscle from (290 50±20 18)PU to (691 39±102 07)PU,and in ear from (5 36±3 26)PU to (19 78±10 10) PU following treatment.Conclusions:It is suggested that high doses of anisodamine and dexamethasone can improve the microcirculation in rabbits with MODS.
出处
《中国危重病急救医学》
CSCD
1997年第12期718-719,共2页
Chinese Critical Care Medicine
基金
国防科工委卫生部重点科研课题
关键词
山莨菪碱
地塞米松
微循环
MODS
治疗
multiple organ dysfunction syndrome
anisodamine
dexamethasone
microcirculation
