摘要
动态检测了34例1993年6月～1994年5月在我校附属医院住院确诊的急性散发性戊型肝炎患者血清IgM、IgG抗-HEV变化。15例患者IgM和IgG同时阳性。16例平均随访观察303d（6个月～15个月）。结果：IgM、IgG抗-HEV阳性最早出现在黄症后第3天；黄疸后10d阳性率分别达86．7％和100％。两抗体在病初1周时滴度最高，以后缓慢下降，IgM下降较快，病程2月时所检患者均降至不能检出水平；IgG抗体除1例外均在1年左右阴转。ALT在抗体出现后很快下降，6周降至近正常水平。IgM抗-HEV检出率仅44．1％，故不宜仅以此作为急性戊型肝炎诊断标准，应结合IgGJ立体动态变化，综合判断。
Serum IgM, IgG anti-HEV in 34 patients diagnosed as acute sporadic hepatitis E were sequentially determined from June 1993 to May 1994- 15 of them were positive both for IgM and IgG anti-HEV. 16 of the 34 patients were followed up for 303 days (6 to 15 months ). The result showed: IgM and IgG anti-HEV were detectable on day 3 after jaundice. On day 10, the positive ratesof IgM and IgG were 86. 7% and 100%, respectively. The titers of the two antibodies were the highest initially, and decIined slowly there-after. IgM antiHEV became negative within 2 months after onset of the disease, IgG anti-HEV became undetectable after about l year. ALT decreased quickly after the antibodies had become positive and turned to normal range within 6 weeks. The positive rate of IgM antiHEV was low, only 44. 1 %. one should confirm acute hepatitis E not only by the positiverate of IgM antibody, but also by considering sequential titers of IgG antibody.
出处
《西安医科大学学报》
CSCD
1997年第4期493-494,共2页
Journal of Xi'an Medical University(Chinese)
